Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
CA
H2O + CO2 H2CO3 H2CO3– + H+
Acetazolamide has weak diuretic action.
It significantly enhances urine K+ excretion.
The loss of HCO3– anions decreases blood
alkaline reserve (for 48–72 h) and causes
metabolic acidosis. In this state the drug
becomes ineffective.
(amiloride/hydrochlorothiazide)
has the same indications too.
5. Osmotic diuretics
60–80%
After oral administration Mannitol is not
absorbed and has laxative effect. After i.v.
administration it is not metabolized, it
filtrates in the glomerulus and not reabsorbed
in renal tubules, causing increased osmotic
pressure and excretion of isoosmotic equivalent
of water. It increases blood flow in 30%.
Мannitol does not influence renin synthesis.
Rhizoma Graminis
(Couch-grass) Fructus Petroselini
Stipites Cerasorum (Parsley)
(Cherry) Stigmata Maydis
Fructus Faseoli sine semine (Maize, corn)
(Haricot)
Rubia tinctorum L. (madder). Radix Rubiae
contains 2–3% di- or trioxyanthraquinones
glycosides, flavonoids and other bioactive
substances with diuretic, urolitholytic and
spasmolytic effects.