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The document discusses ketone bodies, which are synthesized in the liver from acetyl CoA and can act as an alternate fuel for tissues. The three major ketone bodies - acetone, acetoacetate, and beta-hydroxybutyrate - are transported via the bloodstream to peripheral tissues where they can be converted back to acetyl CoA and enter the TCA cycle or be used directly as an energy source. Their production is regulated at multiple levels to provide energy to tissues when acetyl CoA levels in the liver are high.
The document discusses ketone bodies, which are synthesized in the liver from acetyl CoA and can act as an alternate fuel for tissues. The three major ketone bodies - acetone, acetoacetate, and beta-hydroxybutyrate - are transported via the bloodstream to peripheral tissues where they can be converted back to acetyl CoA and enter the TCA cycle or be used directly as an energy source. Their production is regulated at multiple levels to provide energy to tissues when acetyl CoA levels in the liver are high.
The document discusses ketone bodies, which are synthesized in the liver from acetyl CoA and can act as an alternate fuel for tissues. The three major ketone bodies - acetone, acetoacetate, and beta-hydroxybutyrate - are transported via the bloodstream to peripheral tissues where they can be converted back to acetyl CoA and enter the TCA cycle or be used directly as an energy source. Their production is regulated at multiple levels to provide energy to tissues when acetyl CoA levels in the liver are high.
AND β-HYDROXYBUTYRATE CAN BE CONVERTED BACK TO ACETYL CoA AND OXIDISED BY TCA CYCLE
TRANSPORTED IN THE BLOOD TO
PERIPHERAL TISSUES
CAN ABLE TO CROSS BLOOD BRAIN
BARRIER THEY ARE IMPORTANT SOURCES OF ENERGY FOR PERIPHERAL TISSUES BECAUSE A) They are water soluble B) Synthesized when Acetyl-coA is in excess C) They are used in proportion to the concentration in the blood by extrahepatic tissues. REGULATION REGULATED AT THREE LEVELS