Cori Cycle

Presented by: Aina Doreen N. Delfin

Karina Jane T. Guadalquiver
Cori Cycle

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 Lactic Acid Cycle
● Also known as the “Cori Cycle” – Carl Ferdinand Cori & Gerty Cori
● Low oxygen levels  Anaerobic Metabolism (muscles) a
● Anaerobic exercise  Anaerobic Glycolysis (muscles) b
● Muscles convert Pyruvate into Lactate c
● Regenerates NAD+ levels to facilitate Glycolysis
● Liver takes up Lactate, coverts it to Pyruvate, and then into Glucose d
● Glucose returns to the muscle through the bloodstream for Glycolysis.
● Synthesis of Glycogen will occur if Glucose is not required.

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 Cori Cycle
Muscle Blood Liver
Glycogen Glycogen
glycogenesis
glycogenolysis glycogenesis
glucose-1-phosphate glucose-6-phosphate glucose-6-phosphate
phosphoglucomutase

glucose-6-phosphate
pyruvate gluconeogenesis

glycolysis

pyruvate
lactate dehydrogenase
lactic acid fermentation

lactate lactate lactate

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Significance: Cori Cycle
Prevent Lactic Acidosis in the
Muscles
Production of energy in the
muscles during activity in
conditions where oxygen levels are
low.
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 Thank You
Resources:
● Voet, D., & Voet, J. G. (2011). Biochemistry (4th ed.).
● Rodwell, V. W., Bender, D. A., Botham, K. M., Kennelly, P. J., & Weil,
P. (2015). Harper's Illustrated Biochemistry (30th ed.).