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Development
Growth
Tissue Repair
Immune Expansion
Cells respond to signals and divide only when it is
necessary
When growth is finished or a tissue has been
repaired cells stop dividing
The Cell Cycle
Divide only when they receive positive signals
proto-ocnogenes
Stop dividing if there are mutations
tumor suppressors
Anchorage dependence
Contact inhibition
Need blood supply
Telomere shortening limits th4e number of cell
divisions
Tissue repair
GROWTH FACTORS
signals the surrounding
cells to start dividing
Example: Platelets Derived Growth Factor
(PDGF)
Secreted by platelets
Promotes cell growth after wounding
Discovered as necessary for cells to divide in
culture
DNA
NUCLEUS Transcription
Hyperactive
Normal product relay protein
of ras gene (product of
ras oncogene)
issues signals
on its own
Relay
proteins
Transcription factor
(activated)
DNA
NUCLEUS Transcription