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oxaloacetate
OBJECTIVES
To know what happens to Acetyl CoA? What is meant by
citric acid cycle(also called TCA cycle or Krebs cycle)?
Significance of the TCA cycle.
Reactions of TCA cycle.
Energetics of the TCA cycle
Regulation of the citric acid cycle.
Inhibitors of the enzymes of the TCA cycle.
Amphibolic nature of citric acid cycle.
Citric Acid Cycle
succinate thiokinase
Succinate + GTP+ CoA
This is a substrate level phosphorylation reaction
wherein a high energy phosphate is generated
from the energy trapped in thioester bond of
Succinyl CoA.
Step 6 : Formation Of Fumarate
• Succinate is further dehydrogenated to fumarate,
this reaction is catalyzed by the enzyme succinate
dehydrogenase.
• It is the only dehydrogenation reaction that
involves direct transfer of hydrogen from the
substrate to FAD without participation of NAD.
Ans : 2 ATP’s
Regulation Of Citric Acid Cycle
• Isocitrate Oxalosucccinate
NADH