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HYPERTHYROIDISM
An overview
DR PRAVEEN SHETTY
DEPARTMENT OF INTERNAL
MEDICINE
Thyrotoxicosis
Defined as the clinical,physiologic,and
biochemical findings that result when the
tissues are exposed to,and respond to,excess
thyroid hormone.
Rather than being a specific
disease,thyrotoxicosis can originate in a
variety of ways.
RAIU is subnormal
Hyperthyroidism
Others:
Heat intolerance
Increased sweating
Fatigue
Gynaecomastia
Palmar erythema, Onycholysis
Manifestations of Graves disease
Anxiety
Pheochromocytoma
Hydatidiform mole
Ectopic thyroid tissue(struma ovarii)
Factitious thyrotoxicosis
Investigations
Thyroid function test:
TSH- Undetectable
T4 - Raised
T3 - Raised
RAIU- Raised
TSH-receptor antibodies(TRAb)-elevated in
Gravess disease
Isotope scanning- Increased uptake
Other non specific findings
HYPERTHYROIDISM
Type title here
18-24 months
Side effects- Rash
Leukopenia
Agranulocytosis
Control of adrenergic symptoms
Adrenergic antagonists:
Propranolol-40-120mg/day
Ablative therapy(Surgery &
Iodine)
Indications:
Relapse or recurrance following drug
therapy
A large goiter
Failure to follow medical regimen.
Radioactive iodine is simple,effective and
economical
Complications of ablative
therapy