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PRESENTED BY GUIDED BY
Mr. Amit N. Chavan Prof. Dr. Ramesh Sawant
(M. Pharm. Pharmaceutics) M.Pharm., PhD
1st SEM., Roll no. 05 (Pharmaceutical
Chemistry)
Dr. V. V. P. Fs COLLEGE OF
PHARMACY, VILAD GHAT,
AHMEDNAGAR
NUCLEAR MAGNETIC RESONANCE
(NMR Spectroscopy)
A spectroscopic technique that gives us information about the
number and types of atoms in a molecule.
Nuclear magnetic resonance spectroscopy is a powerful
analytical technique used to characterize organic molecules by
identifying carbon-hydrogen frameworks within molecules.
SPINNIG NUCLEUS:
proton acts as a tiny spinning bar magnet and possesses both
electrical charge and mechanical spin.
NMR is the most powerful tool available for organic structure
determination.
It is used to study a wide variety of nuclei:
1. 1H
2. 13C
3. 15N
4. 19F
5. 31P
Many atomic nuclei behave as if they spin on an axis of rotation
Nuclei are positively charged
These spinning nuclei generate tiny magnetic fields
Tiny magnets interact with an external magnetic field, denoted
B0
Proton (1H) and carbon (13C) are the most important nuclear
spins to organic chemists
When applied
When energy frequency is
in the form of equal to Absorption of
radiofrequency precessional energy occurs
is applied
frequency.
12 13
C-NMR C-NMR
no peak Gives peak
6P+6N=12 6P+7N=13
13C CHEMICAL SHIFTS
Natural abundance-
13C natural abundance is very low (1.1%).
Gyro magnetic ratio-
13C nucleus gyro magnetic ratio is much lesser than proton
nucleus. 13C-1.404; 1H-5.585.
Coupling phenomenon-
13C & 1H have I=1/2 so that coupling between them probably
occur.