Connective tissue cells

PERSENTED BY:
Marwan Ahmed ElMahalawy 5216306
Marwan Khaled Omar 5216307
Mohammed Mahmoud Nasser 5216290
Mohammed Mahmoud Abdelazim 5216288
Mohannad Mohammed Mustafa 5216330
Mohammed Mamdouh Ghazi 5216293
Mohammed Essam Mohammed Aly 5216277
First type:
Fixed or permanent cells
Are native to the tissue in which they are found:

Undifferentiated mesenchymal cells

Fibroblasts
Fibrocytes
Macrophages
Fat cells
1- Undifferentiated mesenchymal cells:

- Cytoplasm is faint basophilic.

- Theyre small stellate cells with thin cytoplasmic processes.

- Function: Theyre STEM CELLS, can divide and differentiate into

many types of CT cells.
2- Fibroblasts

- Most common cells in Ct.

- Are spindle- shaped branching cells.
- Basophilic cytoplasm, rich in rER & well developed Golgi complex.
- Have large euchromatic, oval nucleus
- Function: synthesis and secretion of CT Matrix.
3- Fibrocytes

- Have small size, dark nucleus with fewer rER.

- Once fibroblasts synthesize in the matrix, they become less active
fibrocytes.

- Function: maintenance of connective tissue matrix.

4- Macrophages

Are large irregular with pseudopodia.

Are derived from the circulating blood monocytes which leave the blood
stream to migrate into the CT.
Have kidney-shaped eccentric nucleus and eosinophilic cytoplasm with
many lysosomes and phagosomes.

Function: phagocytosis of bacteria, cell debris, malignant and virus

infected cells.
5- Fat cells

Are large cells, polyhedral in shape.

By H&E, The cytoplasm is empty ( The large single lipid droplet is dissolved
during histological slide preparation ) with peripheral flattened nucleus
signet ring appearance.
Stain : Osmium tetroxide, adipocytes appear black in color.

Function: Storage of fat.

Second type:
Wandering Cells
Are immigrant cells usually from blood or bone marrow.
Some retain their own characteristics and may take up
permanent residence there:

Blood leukocytes
Mast cells
Plasma cells
6- Leukocytes

Theyre circulating in blood stream and then migrate into the CT to perform
their specific function.

Types: neutrophils, eosinophils, basophils, lymphocytes and monocytes .

7- Mast cells

The cytoplasm is full of basophilic granules that may obscure the central
nucleus.
A staining feature is Metachromasia i.e. by toluidine blue gives a purple color
instead of blue, due to the acidic glycosaminoglycans of their secretory
granules.

Function:
These cells can initiate local inflammatory response when release the content of
their secretory granules. These includes:
1- Heparin : as anticoagulant
2- Histamine : causes allergic reaction (edema, hypotension, bronchospasm and
skin rash)
Thank you