fights a large number of bacteria's and there are the narrow spectrum antibiotics which only fight few bacteria's Classes of ANTI-BIOTICS
BASE ON THERE USES TYPES OF ANTI-BIOTICS
Antimetabolites. Bacteriostatic Protein synthesis inhibitors. bacteriocidal DNA gyrase inhibitors. (E.T.C) BACTERIOSTATIC ANTI-BIOTICS They are the type of antibiotics that only helps the white blood cells to fight against the harmful bacteria but they are so lazy that they dont kill the bacteria themselves, they just weaken it and they are the most common type of antibiotics like the protein synthesis inhibitor. BACTERIOCIDAL ANTI- BIOTICS
They are the type of antibiotics that
completely take over the job of the immune system in fighting the harmful bacterial by completely fighting it over and they are no there to assist the immune system as they are just there to tell the immune system that they are more powerful and are better than the immune system when it comes to fighting bacteria. A very common example is penicillin, it destroys the cell wall of the bacteria. COMMON ANTI-BIOTICS AND THE WAY THEY WORK ABOUT.
Antimetabolit These type of antibiotic target the metabolic
es pathways which causes death as it blocks the (Sulphonamid production of the bacteria nucleic acid. es) DNA gyrase Its a type of antibiotics that stops the inhibitors(qui bacterial DNA coiling up so it no longer fits nolone) within the cytoplasm of the bacteria. Protein Its a type of antibiotics that interrupt the synthesis transcription and translation so no protein is inhibitors( tet formed. racyclines) Penicillin These type of antibiotic are the ones that weakens the cell walls of the bacteria which means that the content of the bacteria would split out as the walls wont be able to keep it. Effectiveness of antimicrobial drugs 1.CONCENTRATION OF DRUG IN AREA OF BODY 2.PH 3.SUSCEPTIBILTY OF PATHOGEN TO PARTICULAR ANTIBIOTIC 4.HOW EASILY DRUG CAN REACH TISSUE AND HOW QUICKLY IT IS EXCRETED An antiobiotic works only if Microbe has a binding site for the drug A biochemical pathway or metabolic process in microbe with which antibiotic can interfere
Mechanisms of antibiotic resistance
Bacteria becomes resistant by mutation , mutation results in one of the following new biochemical pathway makes cell wall impermeable to antibiotic ( e.g ancomycin) Gets rid of cell wall ( e.g mycoplasma)
Acquires a antibiotic destroying gene ( e.g penicillin , ampicillin)
creating efflux pumps
Hospital acquired infections Superbugs are found mostly at hospitals and care homes , where patients are ill or have had surgery and there is a lot of antibiotic use codes of practice have been developed in order to control infection and prevent it MRSA (methicillin resistant staphylococcus aureus)
Staphylococcus aureus is on human skin and nasal passage and causes no
problem If it goes into the body it causes infections resulting in boiling and abcesses Excessive treatment using methicillin gave rise to mrsa Mrsa produces methillinase , destroying antibiotic Now mrsa infections are treated using high doses of sparingly used antibiotics C.difficile
C.Difficile means clostridium
difficile. It a type of anaerobic bacteria a obligated anaerobic bacteria that lives in human gut and also compete with the guts normal flora. This bacterium is a very dangerous one and can be spread easily just by touching and also can survive a long and dry condition YUCK!!!!!!! The end fellas Dont ask me any question cause the thing goes..