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MANAGEMENT OF
DEMENTIA
3dS OF GERIATRICS
ALZHEIMERS DISEASE
-Although the aging brain undergoes
many developmental changes, these
changes do not significantly interfere with
the daily functioning of most older adults.
DEMENTIA
ALZHEIMERS DISEASE
-HALLMARKS OF AD:
1. Beta-Amyloid Plaques
2. Neurofibrillary tangles
1. ALZHEIMERS DEMENTIAL
-most common type of dementia ; (50%-
70% of all cases)
2. VASCULAR DEMENTIA
-2nd most common type
3. MIXED DEMENTIA
-AD plus Vascular Dementia
TYPES OF DEMENTIA
1. AGE
-doubles every 5 years after age 65 years
2. FAMILY HISTORY
-first degree relative with AD
3. GENETICS
-APOLIPOPROTEIN E-e4 (APOE-e4)
RISK FACTORS OF DEMENTIA
3 STAGES
1. MILD
Subtle, unnoticed, just getting older
2. MODERATE
Behavioral and psychological symptoms of demential (BPSD)
3. SEVERE
requires total care and will die because of complications
Pharmacological Intervention for
Dementia
1. Cholinesterase inhibitors (CEIs)
-blocks cholinesterase enzyme ;
(DONEPEZIL, RIVASTIGMINE, GALANTAMINE)
Acetylcholine
-is a neurotransmitter in the brain, known to be important for memory.
Medication/Disease that inhibit acetylcholine interfere with memory.
Pharmacological Intervention for
Dementia
2. N-methyl-D-Aspartate (NMDA)
Receptor antagonist
-protect neurons from glutamate excitotoxicity without completely
eliminating the glutamate necessary for normal neurological function.
DELIRIUM