FeatureFeature Tuberculoid LeprosyLeprosy

Tuberculoid Lepromatous LeprosyLeprosy

Lepromatous
limited limited diffuselydiffusely
over theover
skinthe skin
Presentation
Presentation few hypoesthetic,
few hypoesthetic, LeonineLeonine
facies facies
hairlesshairless
skin plaques
skin plaques
ErythemaErythema
nodosum nodosum
leprosum leprosum

NumberNumber
of Lesions
of Lesions One or few
One or few Many lesions
Many lesions
Tissue Destruction
Tissue Destruction Little Little MarkedMarked
NumberNumber
of acid-fast
of acid-fast
Few Few Many Many
bacilli bacilli
Likelihood of
Likelihood of
Low Low High High
transmitting leprosy leprosy
transmitting
Cell-mediated
Cell-mediated
PresentPresent ReducedReduced
or absent
or absent
responseresponse
to M. Leprae
to M. Leprae
ImmuneImmune
responseresponse Th1-type
Th1-type Th2-type
Th2-type
Lepromin Test
Lepromin Test PositivePositive NegativeNegative
Rifampicin +
Rifampicin +Rifampicin + Dapsone
Rifampicin +
+ Dapsone +
Treatment
Treatment
DapsoneDapsone Clofazimine
Clofazimine