Practice problems

A 400 mg dose of a drug was given to a 60 kg

woman. Extrapolation of the linear portion of
the drug disposition curve intersects the Y-axis
at 30 mg/L. What is the volume of
distribution?
 If a drug has an elimination rate constant (Ke)
of 0.3 days-1, how much time is required for
elimination of 95% of the drug?
 3. A drug was present in the plasma of a
patient at a concentration of 400 g/ml. 7
hours later, the concentration was 50 g/ml.
Assuming that the drug is eliminated by zero
order kinetics, how long did it take to reduce
the original concentration by 50%? Assuming
that the drug is eliminated by first order
kinetics, how long did it take to reduce the
original concentration by 50%?
 4. The initial plasma concentration of a drug
given iv at 9:00am is 250 mg/ml. If the half-
life of the drug is 6 hours, perform a
calculation to predict the plasma
concentration will be at 9:00pm same day.
 6. A patient visits her doctor with symptoms
typical of a bladder infection. She is
immediately prescribed a 400 mg dose of
antibiotic (t = 12 h). The corresponding
plasma concentration of drug is found to be
96 mcg/ml. What is the volume of
distribution of this drug?
 The bioavailability of a new investigational drug was studied in
12 volunteers. Each volunteer received either a single oral
tablet containing 200 mg of the drug, 5 mL of a pure aqueous
solution containing 200 mg of the drug, or a single IV bolus
injection containing 50 mg of the drug. Plasma samples were
obtained periodically up to 48 hours after the dose and
assayed for drug concentration. The average AUC values (048
hours) are given in the table below. From these data, calculate
(a) the relative bioavailability of the drug from the tablet
compared to the oral solution and (b) the absolute
bioavailability of the drug from the tablet.