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THERAPY
Indications for Oxygen Therapy
Hypoxemia
Inadequate amount of oxygen in the blood
SPO2 < 90%
PaO2 < 60 mmHg
Excessive work of breathing
Excessive myocardial workload
Factors influencing Oxygen
Transport
Hypoxemia
decrease in the arterial oxygen content in the
blood
Hypoxia
decreased oxygen supply to the tissues.
Causes of Hypoxemia
Shunt
Hypoventilation
As carbon dioxide increases oxygen falls
V/Q mismatching (ventilation/perfusion)
Pneumonia
Pulmonary edema
ARDS
Increased diffusion gradient
asbestosis
Early pulmonary edema
Causes of Hypoxia
Lung disease such as COPD, pneumonia and
pulmonary edema
Strong pain meds
Heart problems
Anemia
Cyanide poisoning
Complications of Oxygen
Therapy
Respiratory depression patient with chronic COPD
who is chronically hypoxic is most affected. Maintain PaO2
between 50 and 65 mm Hg for these patients.
Atelectasis High O2 concentrations in the lung can
wash out nitrogen in lung and reduce production of
surfactant. Maintain FiO2 below 60%.
Oxygen toxicity High O2 concentrations result in
increased O2 free radicals therefore lung tissue toxicity.
This leads to ARDS.
Reduced mucociliary activity Maintain FiO2 below
60%. The beating of cilia in the mucociliary blanket is not
as active when high FiO2 levels are used.
Retinopathy of Prematurity caused by high PaO2
Classification of Oxygen Delivery
Systems
Low flow systems
contribute partially to inspired gas patient breathes
do not provide constant FIO2