Blood Loss

Alex Prodan, Ela Kuklina, Julie-Ann van der

Huizen and Nienke de Vries
Introduction:
Parameters Parameters renal
cardiovascular system: system:
Blood pressure Water secretion
Heart rate Renin secretion
Cardiac output Free angiotensin in
Hematocrit levels plasma
Aldosterone
concentration
 Research Question and
Hypothesis
How do the renal and cardiovascular systems
regulate the acute and prolonged effects of blood
loss?
Hypothesis 1: The hormone levels involved in the RAAS system
increase in the first hours after blood loss occurred.

Hypothesis 2: It is expected that the hematocrit levels take longer

than 3 weeks to return to normal levels
Results: Water Secretion
0.9
0.8
H2O secretion (mL/min)

0.7
0.6
0.5
0.4
0.3
0.2
0.1
0
-0.166 0 0.166 1 24 720
Time (hours)
Results: Renin Secretion
1200

1000
Renin secretion (GU/min)

800

600

400

200

0
-0.166 0 0.166 1 24 720
Time (hours)
Results: Angiotensin
60
Free angiotensin in plasma (pG/ml)

50

40

30

20

10

0
-0.166 0 0.166 1 24 720
Time (hours)
Results: Aldosterone
700
Concentration aldosterone (pMol/L)

600

500

400

300

200

100

0
-0.166 0 0.166 1 24 720
Time (hours)
Results: Blood pressure 135

125
Blood pressure (mmHg)

115

105

Systolic Blood Pressure

95
Diastolic Blood Pressure
85

75

65
-0.166 0 0.166 1 24 720
Time (hours)
Results: Heart Rate
85

83
Heart rate (beats/min)

81

79

77

75

73

71
-0.166 0 0.166 1 24 720
Time (hours)
Results: Cardiac Output
6000

5800
Cardiac output (mL/min)

5600

5400

5200

5000

4800

4600

4400
-0.166 0 0.166 1 24 720
Time (hours)
Results: Hematocrit
46
Hematocrit levels in blood (%)

45
44
43
42
41
40
39
38
37

Time (hours)
 Discussion

Cardiovascular
System Change Renal System Change
Water secretion
Blood pressure
Renin secretion
Heart rate Angiotensin in
Cardiac output plasma
Hematocrit Aldosteron
Conclusion:
Hypothesis supported

Limitations:
Ecological validity
Other influential factors
References:
Pictures:
http://www.clipartkid.com/images/246/wounded-bleeding-http-www-wpclipart-
com-medical-medical-clip-art-zKww1j-clipart.png
https://openclipart.org/image/2400px/svg_to_png/224300/The-Thinker-Auguste-
Rodin-Grayscale.png
Information:
Silverthorn DU, Ober WC, Garrison CW, Silverthorn AC, Johnson BR. Human
physiology: an integrated approach. San Francisco, CA, USA:: Pearson/Benjamin
Cummings; 2009.
Marieb EN, Hoehn K. Human anatomy & physiology. Pearson Education; 2007.
http://www.cvphysiology.com/Blood%20Pressure/BP031
http://www.rnceus.com/cbc/cbchct.html