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Innate Immunity
Barrier Defenses
Cellular Response
Chemical Response
Adaptive Immunity
Cell Mediated Response
Humoral Response
3
First Line of Defense
Innate Immunity (Nonspecific Immunity)
4
Body Passages and Innate
Immunity
Trachea lined with ciliated cells and
cells that secrete mucus.
Esophagus leads to stomach with a pH
of 1-2 (acidic) which kills most
pathogens
Urinary tract has lower pH (again
acidic) and is flushed with urine.
Tear ducts with lysozymes.
Reproductive tract also has a lower pH
(acidic once more).
5
Second Line of Defense
Phagocytes and the Chemicals
Released
Second Line of Defense-
Activation of phagocytes
(leukocytes/white blood
cells)
Made in the red bone
marrow.
Found in connective tissue,
tissue lining organs, lymph
nodes and circulating in the
blood.
Neutrophils and Eosinophils
Neutrophils- are the
first to arrive;
numerous (1 billion
made each day);
survive only a few
days. These are
expendable cells.
9
Dendritic Cells
King of the Immune System
Dendritic cells
are important in
adaptive
immunity as an
antigen
presenting cell
Phagocytes and TLR
Receptors
Phagocytes have Toll-
like-receptors (TLR)
which recognize
signature molecules.
The phagocyte engulfs
the pathogens within a
vesicle and deactivates or
kills the pathogen.
Phagocytes can eat
themselves to death.
Natural Killer Cell
(not a phagocyte)
13
Natural Killer Cells Animation
Phagocytes and Chemical
Response
Phagocytes can
also activate
chemical responses
like the
inflammatory
response and the
production of
antimicrobial
peptides.
Chemical Responses
17
Complement Proteins
Complement Proteins
Complement Proteins Forming Pores
20
Complement Proteins and
Opsonizaton
Complement proteins
along with antibodies will
coat a bacterium.
Phagocytes recognize both
the complement proteins
and the antibody.
Phagocytes will engulf the
pathogen and destroy it.
21
Interferons
4. Histamine is released
by mast cells and basophil
cells which are attracted to
an injury site. When the
skin is penetrated, cells
are ruptured releasing
chemical signals to attract
the mast and basophil
cells. These cells release
histamine.
23
Inflammatory Response
Increases capillary
permeability. The area
becomes swollen, red,
temperature increases from the
increased blood flow.
Phagocytes leave the capillary
bed because they are attracted
histamine and other signals.
Phagocytes clean up
pathogens and cell debris.
24
Homeostasis and Inflammatory Response
25
Fever
Inflammatory response is often
accompanied by fever.
Some cytokines stimulate the brain to
make prostaglandins. These
prostaglandins stimulate the
hypothalamus to a new temperature
set point. The signals the
hypothalamus sends out then:
Constrict blood vessels in the skin
Contract skeletal muscles
Increase heart rate and respiration
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