Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Outcome :
The student will understand :
-The process of hematopoiesis
-The development of mature
blood cells
Hematopoiesis
Hematopoiesis is the process
by which immature precursor
cells develop into mature
blood cells.
A single type of stem cell gives
rise to all the mature blood
cells in the body.
This stem cell is called the
pluripotent stem cell.
STRUCTURE AND FUNCTION OF BONE
MARROW
Bone marrow has a vascular compartment and
an extravascular compartment.
Hematopoiesis takes place in the extravascular
compartment. The daily output of mature
blood cells in bone marrow is : 2.5 billion
erythrocytes, 2.5 billion platelets, 50-100
billion granulocytes. The numbers of
lymphocytes and monocytes is also very
large.
In addition to hematopoiesis , bone
marrow is the site of other activities .
These include :
-The removal of aged and defective
erythrocytes -The differentiation of B
lymphocytes
-It is also the site of numerous plasma
cells.
THE PROCESS OF HEMATOPOIESIS
Pluripotent stem cells multiply to produce
more pluripotent stem cells, thus ensuring
the steady and lasting supply of stem cells.
Some of
the pluripotent stem cells differentiate into
precursor cells that are at least partially
committed to become one type of mature
blood cell.
Pluripotent stem cells multiply slowly
into one of five possible unipotential
stem cells, which then multiply rapidly
into the precursor of the specific
mature blood cell for which they are
destined.
Although the pluripotent stem cells
and the unipotential stem cells cannot
be distinguished from one another
histologically, the precursor cells can
be distinguished with a trained and
practiced eye
Basically an immature, precursor cell
goes
from a cell that is making lots of
protein to a cell that is making much
less protein.
Thus, a cell that is making a lot of
protein will have a nucleus containing
dispersed or active chromatin.
When this cell is making less protein,
the chromatin is condensed or
clumped.
Proerythroblast: nucleus still rather large, taking up most of the
cell; nucleus not condensed; cytoplasm still very blue or basophilic