Liver ischemia/ reperfusion

Inflammato Apopsis and

Liver failure Oxidative ry necrosis
response
Portal Small response:
vein liver Neutrophil
Gut
occlusion remnant barrier Spillage activation
of ROS Cytokine
disfuncti
Portal on production
hypertension-
splanchnic
congestion Intestinal mucosa injury-gut barrier
failure
Bacterial and endotoxin translocation

Mechanism involved in remote injury to the gut mucosa leading

to gut barrier failure after liver ischemia/ reperfusion injury
 Lungs

Myocardium Adrenals

Kidney
Pancreas

Intestine Gut barrier

Distant organs that were implicated in remote injury after

hepatic ischemia/reperfusion injury

Nastos, C; Kalimeris, K; Papoutsidakis, N. et al. Oxidative Med. And

 Liver ischemia/ reperfusion

Oxidative
Vascular control techniques response

Inflammatory Apopsis
Portal response
hypertension Reactive
Cytokine Endothelial
oxygen
Renin-angiotensin transcriptio cell death
species
activation n factor

Acute Kidney Injury

Mechanism involved in remote kidney injury after liver

ischemia/ reperfusion injury