PRAKTIKUM PATOLOGI ANATOMI

FAKULTAS KEDOKTERAN UISU

MEDAN - 2009
 Melanoma is one of the most important
cancers o/t skin, commonly diagnosed in
relatively young people and can be fatal if
untreated.
On average, the age of 17-65 years.
Etiology : exposure to UV radiation,
occupational vs. recreational exposure,
socio-economic status (outdoor sports,
winter sports, sunbathing).
Melanoma may occur de novo, without a precursor
lesion, or may develop within a pre-existing benign
melanocytic naevus
Criteria for clinical diagnosis ABCD
(Asymmetry, irregular Border, uneven Colour,
Diameter > 6 mm)
Prognostic indicators for melanoma,most favourable
when:
Breslow thickness Thin (<1.51 mm)
Histology Superficial spreading melanoma
Age Young
Sex Female
Body site Not on the trunk, hands, feet
Ulceration Absent
Mitotic index Low
 Variants of Malignant Melanoma :
Superficial spreading melanoma
Nodular melanoma
Lentigo maligna
Acral-lentiginous melanoma
Desmoplastic melanoma
Melanoma arising from blue naevus
Melanoma arising in a giant congenital
naevus
Melanoma of childhood
Naevoid melanoma
 Definition:a group of malignant cutaneous
tumours characterised by the presence of
lobules, columns, bands or cords of
basaloid cells (germinative cells).
Epidemiology : develop predominantly in
sun-damaged skin, typically occur in
adults but also develop in children;
arsenic exposure and ionizing radiation
may also induce basal cell carcinomas.
 Variants of basal cell carcinoma :
Superficial basal cell carcinoma
Nodular basal cell carcinoma
Micronodular basal cell carcinoma
Infiltrating basal cell carcinoma
Fibroepithelial basal cell carcinoma
Basal cell carcinoma with adnexal
differentiation
Basosquamous carcinoma
 Are not true neoplasms; associated with
inflammation, allergic or mucoviscidosis.
Appear as soft polypoid masses that extend
from the mucosa into the anterior part o/t
meatus.
Microscopically, the polyps are composed of
a loose mucoid stroma and mucous glands
and are covered by respiratory epithelium.
Nasal polyp can also develop as a
complication of mucopolysaccharidosis
(Hurler-Scheie syndrome).
 Polip nasi ialah massa lunak yang
bertangkai di dalam rongga hidung
yang terjadi akibat inflamasi mukosa
Ditemukan pada pria maupun wanita,
usia anak-anak s/d usia lanjut. Adanya
polip pada anak < usia 2 tahun, harus
disingkirkan kemungkinan meningokel
atau meningoensefalokel.

Etiologi ???