INTERACCIONES

MEDICAMENTOSAS
 INTERACCIN DE MEDICAMENTOS

Se presentan cuando dos o ms medicamentos

se administran de manera simultnea o
secuencial en el paciente y producen un
aumento o disminucin del efecto
farmacolgicos
INTERACCIN DE
MEDICAMENTOS
FACTORES QUE CONTRIBUYEN A
LA INTERACCIN DE
MEDICAMENTOS
Factores modificadores

Paciente Medicamentos Alcohol

Tabaco Alimentos
Clasificacin
 Clasificacion

1. Segn el sentido de la interaccin

2. Segn las consecuencias que produzcan
3. Segn la naturaleza
4. Segn su repercusin clnica
Segn el sentido de
la interaccin
 Segn el sentido de la
interaccin

SINERGIA: ANTAGONISMO:
Se incrementa el efecto Disminucin del efecto
del frmaco de los frmacos.

Sumacin: Medicamentos Ineficacia de uno o de los

o sustancias tienen el dos frmacos implicados
mismo mecanismo de en la interaccin.
accin.

Potenciacin: Los
frmacos producen el
mismo efecto por
mecanismos de accin
diferentes.
Segn las consecuencias
que produzcan
 Segn las consecuencias que
In two or three columns
produzcan

BENFICAS: BANALES: PERJUDICIALES:

Potencian la accin Son aquellas que no Se presentan cuando

de un medicamento tienen importancia las repercusiones
con la clnica. clnicas de dichas
administracin de interacciones son
otro. adversas.

Se antagoniza el
efecto de un
frmaco por otra
sustancia y el
resultado no ayuda
al paciente.

Producen efecto
txico o empeoran
Segn su naturaleza
 Segn su naturaleza

FISICOQUMICAS: FARMACODINMIC FARMACOCINTICA

A: S:
Son aquellas que
interfieren en la Sobre el mecanismo Se producen cuando
integridad, liberacin de accin de un interfieren en la
y solubilizacin entre frmaco. absorcin,
otros, de la forma distribucin, unin a
farmacutica del protenas,
medicamento. . metabolismo o
eliminacin de un
medicamento
Segn la repercusin
clnica:
 Segn la repercusin clnica:

Interacciones muy graves.

Interacciones graves.
Interacciones leves.
Interacciones sin trascendencia
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