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7. Sensitive to interferon
8. No sensitivity to antibiotics
Bacteria + + + + +
Mycoplasma + + + + +
Rickettsia - + + + +
Chlamydia - + + + +
Viruses - - - - -
DNA or RNA
* The arenavirus family (an RNA virus family) appears to package ribosomes 'accidentally'. The packaged ribosomes
appear to play no role in viral protein synthesis.
STABILITY OF VIRUSES
- Stable when added MgCl2, MgSO4,Na2SO4
PH 5.00 -9,00
Nucleotides
Gbr 3.
DNA double helix
DNA double helix
Three dimension
NUCLEIC ACID VIRUS
Either DNA or RNA
DNA virus is always in double
stranded, except Parpovirus in
single stranded.
RNA virus is always in single
stranded, except Reovirus in double
stranded.
NAKED ICOSAHEDRAL
NAKED HELICAL
FIVE BASIC STRUCTURAL FORMS OF
VIRUS SYMMETRY
1. Naked icosahedral symmetry, e.g.
poliovirus, adenovirus, hepatitis A virus.
2. Naked helical symmetry, e.g. tobacco
mosaic virus, so far no human viruses with
this structure known.
3. Enveloped icosahedral symmetry, e.g. herpes
virus, yellow fever virus, rubella virus
4. Enveloped helical symmetry, e.g. rabies virus,
influenza virus, para influenza virus, mumps
virus, measles virus
5. Complex symmetry e.g. poxvirus
Basic Classification of Viruses
- RNA or DNA
- single-stranded or double-stranded
- nonsegmented or segmented
- linear or circular
Nucleic acid
- if genome is single stranded RNA, can
it function as mRNA?
- whether genome is diploid (it is in
retroviruses)
- symmetry (icosahedral, helical,
complex)
Virion structure - enveloped or not
- number of capsomers
GLOSSARY :
1. Capsid : The protein coat that surrounds the
nucleic acid of a virus.
2. Nucleo Capsid : The virus structure composed
of the nucleic acid surrounded by the capsid.
3. Capsomer : Substructure of virus particle.
4. Genome : A set of genes
5. Viremia : Presence of virus particles in the
blood
6. Envelope : A host cell derived membrane,
containing virus specific antigens, thats is
acquired during virus maturation.
T-Lymphocyte
Muh.Asaad Maidin
Penetration and
uncoating
T-Lymphocyte
Package
Pathogenesis in the infected patients involves
1. Transmission of the virus and its entry
into the host.