OSTEOSARCOMA

&
OSTEOARTHRITIS

Cobre
 Osteosarcoma
type of cancer that starts in the
bones
malignant bone tumor
osteoblasts produce malignant
osteoid
cause is not known
associated with specific genetic
changes
 Osteoarthritis
degenerative joint disease or wear and
tear arthritis
disease of the entire joint, involving the
cartilage, joint lining, ligaments, and bone
characterized by:
breakdown of the cartilage
bony changes of the joints
deterioration of tendons and ligaments
and various degrees of inflammation of the
joint lining
 OS OA
males > females
occur in children
and young adults/ males < females
teens occurs age 40 and
2% of all childhood above
cancers 13.9% =25 years and
second incidence older
peak 33.6%= 65+ years
over age 60
10% of all
osteosarcoma
 OS OA
can occur in any commonly used
bones joints
quickly growing Hands
bones Spine
near end of long weight-bearing
bones joints
distal femur
Hips
proximal tibia
proximal humerus
Knees
around the knee
Risk Factors
OS OA
Older age
Having family members
Younger age
with OA
Adolescence Obesity
Having family Previous traumatic Joint
members with OS injury
Certain occupations
Bone deformity such as
unequal leg length,
bowlegs or knocked
knees
Symptoms
OS OA
Joint pain Joint pain and stiffness
Bone fracture Knobby swelling at the
Limitation of motion joint
Limping Cracking or grinding
Pain when lifting noise with joint
movement
Tenderness, swelling,
or redness at the site Loss of flexibility
of the tumor Bone spurs
Diagnosis
OS OA
Physical exam
Biopsy
Imaging tests
X-ray Typical symptoms
Bone scan
Physical exam
CT scan
Imaging Tests
Staging of bone
sarcomas
Treatment
OS OA

Physical measures
Drug therapy
Chemotherapy Topical
Surgery Oral
Limb-sparing surgery Injections
Amputation Surgery
Arthroscopy
Joint replacement
Supplements
Histopath (OS)
Histopath (OS)
Histopath (OS)
 Histopath (OA)

urce: http://www.mdpi.com/1422-0067/17/3/359/htm
 NORMAL With OA

Source: http://www.mdpi.com/ijms/ijms-17-
00359/article_deploy/html/images/ijms-17-00359-g002-1024.png
 NORMAL With OA

Source: http://www.mdpi.com/ijms/ijms-17-
00359/article_deploy/html/images/ijms-17-00359-g004a-1024.png
Advancements
OS OA

Intensity-modulated
radiation therapy Strontium ranelate
(IMRT)
Stem cells
Targeted therapy
Biomarkers
drugs
Monoclonal antibodies
 Sources
http://www.rheumatology.org/I-Am-A/Patient-
Caregiver/Diseases-
Conditions/Osteoarthritis#sthash.o9QkefXt.dpuf
http://www.health.harvard.edu/press_releases/new
-osteoarthritis-treatments-on-the-horizon
http://www.medscape.com/viewarticle/748984
https://www.nlm.nih.gov/medlineplus/ency/article/
001650.htm
https://www.macmillan.org.uk/information-and-
support/bone-cancer/understanding-cancer/types-
of-bone-cancer/osteosarcoma.html#tcm:9-241796