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AP Biology
2007-2008
Phospholipids
Phosphate head
attracted to water
hydrophilic
Phosphate
hydrophobic
Arranged as a bilayer
Fatty acid
repelled by water
Aaaah,
one of those
structurefunction
examples
AP Biology
H2O
salt
polar
hydrophilic
heads
nonpolar
hydrophobic
tails
polar
hydrophilic
heads
AP Biology
waste
lipids
AP Biology
inside cell
APNH
Biology
3
salt
H2O
aa
sugar
outside cell
lipid bilayer
membrane
AP Biology
protein channels
in lipid bilyer membrane
Why are
proteins the perfect
molecule to build structures
in the cell membrane?
AP Biology
2007-2008
I like the
polar ones
the best!
AP Biology
Polar areas
of protein
into membrane
On outer surfaces of
membrane in fluid
AP Biology
H+
H+
Examples
Retinal
chromophore
NH2
aquaporin =
water channel in bacteria
Porin monomer
H2O
-pleated sheets
Bacterial
outer
membrane
Nonpolar
(hydrophobic)
-helices in the
cell membrane
COOH
H+
H
+
Cytoplasm
HO
AP Biology 2
function through
conformational change =
protein changes shape
Enzyme
activity
Cell surface
receptor
Cell adhesion
Attachment to the
cytoskeleton
Antigen
AP Biology
Cell surface
identity marker
Membrane Proteins
Proteins determine membranes specific functions
peripheral proteins
loosely bound to surface of membrane
ex: cell surface identity marker (antigens)
integral proteins
penetrate lipid bilayer, usually across whole membrane
transmembrane protein
AP Biology
AP Biology
Extracellular fluid
Glycolipid
Phospholipids
Cholesterol
Peripheral
protein
AP Biology
Cytoplasm
Transmembrane
proteins
Filaments of
cytoskeleton
Membrane carbohydrates
Play a key role in cell-cell recognition
AP Biology
Any Questions??
AP Biology
AP Biology
2007-2008
Diffusion
2nd Law of Thermodynamics
governs biological systems
Diffusion
AP Biology
Simple Diffusion
Move from HIGH to LOW concentration
passive transport
no energy needed
AP Biology
diffusion
movement of water
osmosis
Facilitated Diffusion
Diffusion through protein channels
HIGH
LOW
AP Biology
The Bouncer
Active Transport
Cells may need to move molecules against
concentration gradient
ATP
HIGH
AP Biology
The Doorman
Active transport
AP Biology
ATP
antiport
symport
Simple diffusion
diffusion of nonpolar, hydrophobic molecules
lipids
HIGH LOW concentration gradient
Facilitated transport
diffusion of polar, hydrophilic molecules
through a protein channel
HIGH LOW concentration gradient
Active transport
AP Biology
ATP
Transport summary
simple
diffusion
facilitated
diffusion
active
transport
AP Biology
ATP
AP Biology
exocytosis
exocytosis
Endocytosis
phagocytosis
fuse with
lysosome for
digestion
pinocytosis
non-specific
process
receptor-mediated
endocytosis
triggered by
molecular
signal
AP Biology
AP Biology
2007-2008
AP Biology
across a
semi-permeable
membrane
Concentration of water
Direction of osmosis is determined by
comparing total solute concentrations
water
AP Biology
hypotonic
hypertonic
net movement of water
AP Biology
freshwater
balanced
saltwater
KABOOM!
example: Paramecium
ex: water continually enters
Paramecium cell
ATP
ATP
AP Biology
plant cells
No problem,
here
turgid = full
cell wall protects from bursting
freshwater
ATP
AP Biology
can die
example: shellfish
solution: take up water or
pump out salt
I
AP Biology
plant cells
plasmolysis = wilt
can recover
will
survive!
saltwater
Thats
perfect!
no difference in concentration of
water between cell & environment
problem: none
AP Biology
balanced
1991 | 2003
Aquaporins
Water moves rapidly into & out of cells
AP Biology
Peter Agre
Roderick MacKinnon
John Hopkins
Rockefeller
.05 M
.03 M
Any Questions??
AP Biology
AP Biology
2007-2008
inside cell
NH3
lipid
salt
polar molecules
H2O
outside cell
sugar aa
H2O
ions (charged)
salts, ammonia
large molecules
starches, proteins
AP Biology
AP Biology
cholesterol in membrane
NO!
OUT
IN
food
carbohydrates
sugars, proteins
amino acids
lipids
salts, O2, H2O
AP Biology
OUT
IN
waste
ammonia
salts
CO2
H2O
products