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Suppose a diagnostic test has a 97% detection rate and a 5% false alarm
rate. Suppose a person selected at random tests positive. What is the
probability that the person has the disease?
It might seem that the odds of having the disease are 0.97/0.05 (i.e.,
the detection rate over the false alarm rate), which corresponds to a
probability of about 95%. But Bayesians know that such an answer is not
appropriate because it ignores the prior probability of the disease, which
presumably is very rare.
Suppose the prior probability of having the disease is 1%. Then Bayes' rule
implies that the posterior probability of having the disease is only about
16%, even after testing positive! This type of example is presented over
and over again in introductory expositions (e.g., pp. 103-105 of DBDA2E),
emphatically saying not to use only the detection and false alarm rates,
and always to incorporate the prior probabilities of the conditions.
Example
The role of the Bayes factor in the usual simple disease-diagnosis or drugscreening situation described below.
A person is randomly selected from a population in which the prior
probability of having a particular disease is 1%. Denote the condition of the
person by the variable M, which can have two values, either M=healthy or
M=disease. The prior probability can be written as p(M=disease)=0.01, and
hence p(M=healthy)=0.99.
Summary
Bayes factors represent the weight of evidence in the data for
competing hypotheses. Bayes factors are the degree to which the
data shift the relative odds between two hypotheses. There are
principled reasons why we should interpret the Bayes factor as a
measure of the strength of the relative evidence.
The Bayes factor is intimately linked to the predictions of a
hypothesis. Because the evidence for a hypothesis given by the
degree to which it has predicted the observed data, hypotheses
that do not have predictions for data cannot accumulate evidence.
Hypotheses with no predictions, such as 0 are not allowed.
The Bayes factor can be directly interpreted, without recourse to
labels. The strength of the Bayes factor is reflected by the fact
that it is a multiplicative change in odds. However, some authors
provide labels to help interpret evidence.
BAYES FACTOR
> 100
30 100
10 30
LABEL
3 10
13
No evidence
1/3 1
1/3 1/10
1/10 1/30
1/30 1/100
< 1/100