Pathophysiology of Jaundice -> Alcoholic stool

Unconjugated

Hepatocellular

Inadequate
intracellular transport
or enzyme systems

Hepatocellular
injury

Destruction of red blood cells

or muscle tissue exceeds
normal conversion limit

Movement of
bilirubin
diglucoronide into
Biliary system

Conjugation of bilirubin into

bilirubin diglucoronide by
inadequate intracellular
transport or enzyme systems

Cholestatic

Obstruction/dama
ge in the hepaticbile capillary
membrane
Inability to
transport bilirubin
into small
intestine

Regurgitation of bile
pigments into
bloodstream

Bilirubin

Bilirubin

Bilirubin
Hyper
bilirubinemia

bilirubin
secretion
Urobilinoge
n
Stercobu
lin
Clay/Pale colored stool (Alcoholic
stool)

Yellowish
discoloration of
the skin/eyes