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Documenti di Professioni
Documenti di Cultura
Paracelsus 1493-1541
Hieronyma Spara
formed a society to teach
women how to murder their
husbands (arsenic)
To aid women to inherit money
(1600s)
Father of Toxicology
Mathieu Orfila
father of forensic toxicology
published in 1814 Trait des
poisons
which described the first
systematic approach to the study
of the chemistry and
physiological nature of poisons
Aspects of Toxicity
Dosage
The
Lethal Dose
LD50 refers to the dose of a substance
that kills half the test population,
usually within four hours
Expressed in milligrams of substance
per kilogram of body weight
Toxicity Classification
LD50 (rat,oral)
Correlation to
Ingestion by 150-lb
Adult Human
Toxicity
<1 mg/kg
a taste to a drop
extreme
150 mg/kg
to a teaspoon
high
50500 mg/kg
to an ounce
moderate
5005,000 mg/kg
to a pint
slight
515 g/kg
to a quart
practically nontoxic
Over 15 g/kg
relatively harmless
Symptoms of Poisoning
Type of Poison
Carbon monoxide
Sulfuric acid
Hydrochloric acid
Nitric acid
Phosphorus
Cyanide
Arsenic,
mercury
Symptom/Evidence
Lead Poisoning
Lead-
Lead
Brain
damage
Affecting memory & thought processes