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Introduction
1. The only pathogenic amoeba among al
l of the intestinal amoebae
2. Infecting perhaps 10% of the world's p
opulation.
3. Lead to invasive amoebiasis.
Entamoeba histolytica
Entamoeba dispar
Major
pathogen
Trophozoite
& Cyst
oral-faecal transmission
Cyst (non-motile)
(1) 10-20 mocrometers in size
(2) spherical in shape
(3) 1-2 nuclei (immature cyst); 4 nuclei (mature cy
st-infective stage).
(4) inclusions:(become smaller and smaller as the
cyst ages)
glycogen vacuole appears as a clear space; food
reservoir
chromatoid body dark blue rods or dots; its fun
ction is not known
Life Cycle
1
Pathogenic factors
1.
Pathology and
Clinical Manifestation
Pinpoint
Clinical classification
Asymptomatic
es (E. dispar?)
Sympomatic cases <10%
8-10% dysentery, colitis, etc
2% invasive amoebiasis
0.1% deaths
A. Intestinal amoebiasis
a. dysentery: dysenteric stools (pus and blood w
ithout feces). fever, dehydration, and electrolyte ab
normalities. Tenesmus and abdominal tenderness.
b. non-dysenteric colitis
c. appendicitis
d. amoeboma:may become the leading point of
an intussusception or may cause intestinal obst
ruction.
B. Extra-intestinal amoebias
is
a. Hepatic
(1) acute non-suppurative
(2) liver abscess: right upper quadrant pa
in, referred to the right shoulder. tender.
b. Pulmonary
B. Extra-intestinal amoebias
is
c. Brain
d. Skin, perianal infection
e. Other extra-intestinal amoebiasis
Diagnosis
1.Stool examination
specimen
method
diseases
remarks
trophozoite
cyst
feces
feces
amoebic dysentery
chronic intestinal
amoebiasis or carriers
Diagnosis
2.
abscess
Prevention
Human