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– A non immunologically
– A response of the mediated event,
immune system usually triggered by small
involving molecular weight
antigen consisting of chemical substances, and
biologically active
protein or a molecule
components of foods
linked to a protein
Histamine in Food Allergy
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Signs of Possible Histamine Intolerance
1. Skin tests:
– “Mildly positive” to multiple allergens
– Large reaction wheal to histamine control
2. Unusually sensitive to alcoholic beverages
3. Sensitive to fermented foods, cheese&vinegar
4. Sensitive to benzoate-containing food.
5. Dermatographia
6. Indicators of reduced histamine metabolism:
– Elevated plasma histamine (>2 ng/ml)
– Reduced DAO activity (<0.7 nkat/L)
7. Normal serum IgE.
8. Positive family history
Histamine poisoning