WearMeSoC

Multi Functional Wearable Wireless Medical Monitoring Based on A Multi Channel Data
Acquisition and Communication Management System on a Chip

Prof. Dr. Qiuting Huang, 26.04.2016

Qiuting Huang | 26.04.2016

IoT: The Next 20 Billion Connected Devices

Energy
Management Health, Fitness
Environmental Transportation

Qiuting Huang | 26.04.2016

Growing Interests in Wearable Devices

Qiuting Huang | 26.04.2016

Challenges

Indeed
Opportunities
But

Escalating Medical Costs

Lots of Promises
Wireless
Revolution
Lot of Potential
Advent
of M2M and IoT
Some Appplications Are Clear
Smartphones
and Tablets
More To Be Discovered

Nano Electronics Integration

Will Be Fragmented

Potentially Benefiting Healthcare

Need Platform
[Source: Swiss Federal Statistical Office]

Aging Population
Growing need of the elderly
Silent Suffering

Need Miniaturization
Need Low Cost
Need Plug-and-Play

Main Objective:
Develop technologies essential to miniaturize wireless monitoring, and
demonstrate its effectiveness in real medical use cases
Qiuting Huang | 26.04.2016

The Needs Clinicians Take Matters Into Their Own Hands

Auricall Monitoring Konzept

Real-time Auswertung

Frherkennung von Tendenzen

)))))

live-transmission

https://

Bluetooth

)))))
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On-line berwachung
)))
)))))

)))))))))))
GPRS

)))))
Swissphone
GPRS General Packet Radio Service, data transfer via mobile phone network
https Hypertext transfer protocol secure, secure internet connection

Pre Nano Tera Research

Qiuting Huang

26.04.2016

The Needs Available Components Limit Miniaturization

Auricall Pre Nano Tera Research

A new device for a non-invasive, wireless,
continuous monitoring of oxygen saturation
and heart rate in patients with heart failure*

Hardware Konzept

Standard-Klebelektroden

EKG (eine Ableitung mit zwei Elektroden)

Sauerstoff-Sttigungsmessung
* Sudano I, Flammer AJ, Hermann F, Syburra T, Kaiser P, Hirt A,
Hermann M, Corti R, Ruschitzka F, Zund G, Noll G. Int J Cardiol.
2008 Sep 16;129(1):141-3.
Qiuting Huang

26.04.2016

WearMeSoC Objectives
Electrode
Connectors

Battery
Antenna
Radio
Memory

Planned
SoC
Micro SD Card Holder
Figure 2 Functional Outline of Wearable Wireless Monitor SOC
(Page 7 of the 2012 Proposal)

Part of Slide Shown in May 2013 NT Convention

Qiuting Huang | 26.04.2016

Vision: Highly Integrated Wireless Med Platform

Plug and Play for Clinicians and Patients

Qiuting Huang | 26.04.2016

Journey Towards Miniaturization and Wearability

Qiuting Huang | 26.04.2016

Start of WearMeSoC, Handheld Version

Too many chips spoil the broth

Qiuting Huang | 26.04.2016

| 10

Skin Interface to Electrode

Addressing Wearability:

DC Drift and Motion Artefacts

AFE Must Not Saturate

Proper Choice of HP Corner

Mains Interference

Location Dependent
Qiuting Huang

| 26.04.2016 |

11

Data Acquisition Chip with Interference Cancellation

Data Acquisition ASIC:

CMRR:

101dB

Inp. Impedance: IRNoise (1100Hz):

Tolerated Offset:

235M

300mV

With signal reconstruction:

0.82VRMS

Max. DR:

Max. PWR:

107.6dB

5 mW

Qiuting Huang

| 26.04.2016 |

12

EMG: Hand Gesture Recognition

(Prof. Benini, ETH and Univ. Bologna)

EMG controlled hand prosthesis

JTAG/SWD DIGITAL ANALOG
SD
CARD
BLUETOOTH
MODULE
BLUETOOTH
REGULATOR

PRESSURE
SENSOR

BATTERY

SENSORS
REGULATOR

I2C

JTAG

USART

IMU

USB

Further Miniaturization Desirable

SPI

ARM Cortex M4
MCU

MCU
REGULATOR

SPI

CEREBRO

WearMeSoC AFE

ELECTRODES
CONNECTOR

CEREBRO DIGITAL CEREBRO ANALOG

REGULATOR
REGULATOR

POWER
MANAGEMENT

Qiuting Huang | 26.04.2016

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Peripheral Neural Interface to Visceral Organs

- Understanding the Regulation of Blood Pressure

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| 26.04.2016 | 14

Need for Miniaturization

Research Platform for Bioelectronics

Qiuting Huang | 26.04.2016

15

Integration for Miniaturization

Qiuting Huang

26.04.2016

16

Nano-Electronics Provides the Tiniest of Neural

Interface
Courtesy of Prof. S. Lacour, EPFL

Courtesy of Dr. Q. Wang, CHUV

Stimulating
180

A
BP
mmHg

ADN

(20s)

14 Test Cortec i n Wi star rat 320g_1.5%Is ofluthane and 1.5L/min O2_Cor tec_ETH stimulation ADN_3V_0.2mA_200us _20Hz _20s

172
164
156

BP (mmHg)

148
140
132
124
116
108
100
92
84
76
68
60
52
44
36
2h57'00

480

B
HR
Beat/min

Stimulating
ADN(20s)
2h57'20

2h57'40

2h58'00

2h58'20

14 Test Cortec i n Wi star r at 320g_1.5%Isofluthane and 1.5L/mi n O2_Cor tec _ETH sti mulation ADN _3V_0.2mA_200us
_20Hz
_20s
Heart Rat
e

460
440
420
400
380
360
340
320
300
280
260
240
220
200
180
160
140
120
100
2h57'00

C
RSNA
V

2h57'20

2h57'40

2h58'00

2h58'20

Stimulating ADN
(20s)

Time (s)

Qiuting Huang |

26.04.2016 | 17

VivoSoC v1.0: Biomedical Data Acquisition SoC

(in collaboration with Prof. L. Benini)

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Evolution Towards Miniature

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Match Box Sized Demonstrator:

Electrocardiograph and Pulsed Oximetry with Wireless Connectivity

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Match Box Sized Demonstrator for ECG

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Integrated Circuit for Pulse Oximetry

Is a non-invasive measurement method for blood

oxygen saturation (SpO2) and heart beats per
minute (BPM)
Is widely used in patient monitoring in:
anaesthesia
intensive care stations

ambulant care

Interest in wearable oximeters:

Long-term monitoring
Monitoring in stress tests
Medical research, e.g., in pneumology

StateoftheArt:
Left:NoninOnyxforambulantusechecking
notmonitoring
bot:MasimoRad5vforstationaryuseincl.
monitoring
2 =

ac
dc
ac
dc

VS
vs

VS
ir
IR

IR

Qiuting Huang

| 26.04.2016 |

22

Wearability Challenges

Power consumption

Integrated Systems Laboratory

Usually, LED 50mA

Ambient Light

Adds an offset wrong result since

ambient is uncorrelated to LED.

Motion

Ambient Light

Results in motion of the venous blood

lower than actual saturation is measured
Pulsatile signal and motion artifact are
difficult to separate (underdetermined
system)

Amplifier Offset

armswinging

VS
VS
IR
IR

=: =

+ v

=: = +
vs

a
a = IR
a

vs

v
v = IR
v

still
vertical
movement

horizontal
movement

Oscillating
finger

Rawsignalsperturbedbydifferentkindsofmotion.

Qiuting Huang

| 26.04.2016 |

Integrated Circuit for SpO2

Qiuting Huang | 26.04.2016

| 24

Match Box Sized Demo Board SpO2

Wireless Connection to Tablet

User Interface Both for
Device Set Up and Result
Display
Same GUI for ExG and SpO2
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Match Box Sized Demo for SpO2 4 Wavelengths

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SpO2 Implant for Chronic Study of Hypertension

common
carotid artery
photodiode

[1] Online, http://www.biologycorner.com/worksheets/rat_circulatory.html,

06.03.2016

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Plethysmography while Stimulating ADN

Measured light intensities,

i.e. inverse of the absorption

respiratory pulse
pressure variations
(PPV)
Effect of ADN
stimulation

Raw Plethysmographs
IR
VS

Catheter reference:
Blood Pressure
BPM

Short term pressure variations can be observed in the plethysmographic

signals (actually how plethysmography works):
Fluid Pressure artery dilation light absorption
Qiuting Huang

| 26.04.2016

Next Steps

Qiuting Huang

| 26.04.2016

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VivoSoc v2.0: Multi-Sensor SoC

(in collaboration with Prof. L. Benini)
passive sensors

LDOs

temperature
readout
2 channel

Algorithmic
ADC
12-bit

photodiode
readout
3 channels

dedicated analog readout

8 channel biopotential
with continuous lead impedance

SAR ADC
reconfigurable
5-to-14 bit

Bio
Impedance

MUX

CLK

SAR ADC
reconfigurable
5-to-14 bit

UART
SPI slave
SPI master
J TAG
8 GPIOs

PMU
Multi-channel
driver, blocker,
stimulator

configuration
and data BUS

core 0

core 1

core 2

core 3

L2 memory
32 kB SRAM

- gyroscope
- accelerometer
- thermometer
- microphone
- ...

active
sensors

COTS
- LCD display
- SD card
- Image sensor
- Memory

RF

VivoSoC v2.0

Qiuting Huang | 26.04.2016

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Conclusions
High Expectations in IoT Advances, Also for Health

Time is ripe in terms of Smartphones, Connectivity and SoC

Integration Is Catalyst to Success

Miniaturization, Power, Versatility, Wearability

Match Box and Smaller Sized Demonstrators

Driven by Wearable ExG, SpO2 and Bioelectronic Implant

Enabled by Med Monitor SoC and other ICs

Confident in a Achieving the

Ambitious Targets We Set Ourselves

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