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IMPACT ON THYROID
FUNCTION IN
EARLY HEALTHY
PREGNANCY
YULIANA RAMADANI
14120130074
INTRODUCTION
pentung
METHOD
Design :
NEXT..
Analysis
RESULTS
Clinical Characteristics of the 110 Included
Women
1. Their median age was 27.5 y (1840),
2.
their body mass index (BMI) was 22.4 (1645.3)
3.
a weight at inclusion of 61.5 kg (43128 kg)
4.
they were nuliparous in 44.5%.
5.
53% had never smoked, 18% were former
smokers, and 28% were current smokers.
6. 15% had a family history of thyroid disease
7. 82% were born in France (including 56% in the
authors area).
RESULT
Sample characteristic
mean SD
Min
Max
Ioduria g/L
116
139 98
< 15
399
FT4 pmol/L
14,35
14,57 1,65
12.0
19,16
TSH MUI/L
1.18
1.24 0.58
0.13
2.47
FT3 pmol/L
5.0
5.1 0,5
3.8
6.7
TT4 nmol/L
110.7
111,1 23
50,7
167,4
TBG m g/mL
26,7
28,1 7,2
12,8
50
Tg ng/mL
17.4
22,3 17,2
1.3
100
hCG UI/L
62.724
65.289 47.845
1025
220.731
rT3 nmol/L
0,27
0,27 0,07
0.13
0.51
DISCUSSION
DISCUSSION
A.
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C. UIE did not correlate with any parameters of
maternal thyroid function at this stage of pregnancy
in our selected healthy population. We had already
reported this lack of correlation in our previous
study performed during the third trimester [2].
D. Of note, we report a strong correlation of hCG
with UIE. One physiological explanation could be
that hCG stimulates relaxin secretion by the
corpus luteum, which plays an important
physiologic role in the maternal renal adaptation to
pregnancy [31]. We speculate that this could
contribute to gestational increased UIE during the
first trimester.
Ioduria
Negatif
Positif
Usia ibu
r = - 0.2
P = 0.05
Volume tiroid
r = - 0.22
P = 0.03
HCG
r = 0.27
P < 0.01
fT4
r = - 0.27
P < 0.005
rT3
r = - 0.24
P = 0.01
hCG
r = - 0.36
P < 0.0001
r = 0.19
P = 0.06
r = - 0.2
r = 0.44
P = 0.05
P < 0.0001
rT3
r = 0.44
P < 0.0001
/ 3 hCG
r = 0.18
P = 0.058
TSH
Negatif
Positif
fT4
Negatif
Positif
fT3
Positif
Tg
r = 0.22
P = 0.02
rT3
Negatif
Merokok
P = 0.001
Positif
hCG
r = 0.4
P < 0.0001
fT4
r = 0.44
P < 0.0001
TT4
r = 0.5
P < 0.0001
TBG
r = 0.33
P = 0.0005
fT3
r = 0.22
P = 0.02
Tg
Positif
Merokok
P = 0.0001
b hCG
Negatif
Positif
TSH
Ioduria
r = - 0.36
r = 0.27
P < 0.0001
P < 0.01
TT4
r = 0.3
P < 0.005
FT4
r = 0.18
P = 0.058
rT3
r = 0.4
P < 0.0001
TBG
r = 0.40
P < 0.0001
Negatif
Ioduria
r = - 0.22
P = 0.05
Positif
Merokok
Volume tiroid
P = 0.02
CONCLUSION
The absence of correlation between UIE and thyroid tests at that stage of pregnancy