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Dr Mohsina Zubair
Nomenclature
Classification
Occurrance
Function of alkaloids
Isolation, properties of alkaloid, detection
of alkaloids
Quinine
Therapeutic uses of quinine
Morphine
introduction of alkaloids
Nomenclature
i.
A large no: of alkaloids are known and consist of such a variety of molecular
structure that their rational classification is very difficult. Alkaloids are often
classified according to plant from which they are isolated. e.g. cinchona,
opium etc.
Nowadays they are classified according to the heterocyclic ring system,
which is common group of alkaloids. They are classified as follows:
Phenylethylamine alkaloids
ii.
iii.
iv.
v.
vi.
vii.
viii.
ix.
x.
Occurrence of alkaloids
Functions of alkaloids
Isolation
alkaloids are isolated by a general
procedure, recommended by Manske,
is described here. The general
scheme for the extraction of
alkaloids is as follows.
Properties of alkaloids
1.
2.
3.
4.
5.
6.
7.
Detection of alkaloids
Alkaloids are detected by physical methods as
well as by chemical methods.
Physical methods
1. Infra red spectroscopy
2. Ultra violet spectroscopy
3. X-ray analysis
4. NMR spectroscopy
5. Mass spectrometry
6. Optical rotatory dispersion (ORD) and circular
dichroism.
Detection of alkaloids
Infra red spectroscopy studies used to identifying the
several functional group like methylene groups, N-methyl
group, on C-methyl group, heterocyclic ring such as
pyridine, pyrrole etc.
UV spectroscopy are used to indicate the probable
structure of the alkaloids molecule.
X-ray analysis has been used for distinguishing the various
possible alternative structures.
Mass spectrometry has been recently used for determining
the types of nuclues (aromatic and heterocyclic) and the
size and structure of side chains in the various groups.
The stereochemistry of alkaloids is determined by X-ray
analysis, ORD and circular dichroism.
Detection of alkaloids
1.
2.
3.
4.
Quinine
Quinine
Sources. It is obtained from cinchona
ledgeriana and its hybrids.
Extraction. The bark is powdered and mixed
with sodium hydroxide solution and slaked
lime and the librated alkaloids are extracted
with hot petroleum. The separated extract is
shaken with hot dilute sulphuric acid. The
alkaloids passes into the aqueous layer as
sulphate. The solution is then cooled and the
sparingly soluble quinine sulphate crystallizes.
Structure
Properties of Quinine
1.
2.
3.
4.
5.
6.
2.
3.
Morphine
Properties of Morphine
i.
ii.
iii.
iv.
v.
vi.
Question
Q1. explain the nomenclature and classification of
alkaloids ?
Q2. Describe the function and isolation of alkaloids?
Q3. Quinine structure and properties?
Q4. Describe Morphine structure and properties ?
Q5. Define the detection method of alkaloids?