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Dr S A Jayaratne
Dept of Pharmacology
Mechanism of action
Pharmacological effects
Cardiac effects Cause AV block
Cardiac slowing due to its action on
conducting tissue
Vascular effects
Generalised arterial /arteriolar dilatation
reduce BP (not much effect on veins)
Cause coronary vasodilatation
Also used in patients with coronary artery
vasospasms (variant angina)
Phennylalkylamine (Verapamil)
greater effect on heart -vly inotropic effect
& chronotropic effects
Causes arteriolar vasodilation
Some venodilator effect
.Contraindicated in heart failure, bradycardia,
heart block
Indication-cardiac arrythmia
Amlodipine
Has a long t1/2
not contraindicated in heart failure
Nimodipine
Moderate cerebral vasodilating effect
In subarachnoid Haemorrhage ischaemia is due
spasm
Nimodipine selective for cerebral vasculature
Given iv
Hypotension
Sinus bradycardia
AV conduction defects
Severe cardiac failure