MULTIPLE CHOICE QUESTION

ON VITAMIN DISORDER

PRESENTED BYPAPORI BORAH

(INTERN)

1.Malonyl aciduria is seen in deficiency of1.Pyridoxine

2.B12
3.Folic acid
4.Riboflavin
ANS:B12
In B12 deficiency cases ,the excretion of methyl malonic acid
in urine is elevated and these levels are used to access B12
deficiency.
2.BERI-BERI is caused due to the deficiency of1.Thiamine
2.Pyridoxine
3.Ascorbic acid
4.Riboflavin
ANS: Thiamine
BERI-BERI is mostly seen in people consuming exclusively
polished rice as staple food because polishing of rice removes
about 80%of thiamine.

3.A patient with chronic renal failure and bone pain will have
deficiency of which vitamin1.Vitamin A
2.Vitamin B
3.Vitamin C
4.Vitamin D
ANS :Vitamin D
There is decreased synthesis of calcitriol in kidney which is
essential for bone formation.
4.FIGLU excretion test is to estimate deficiency of1.Vitamin K
2.Vitamin B12
3.Vitamin folic acid
4.Niacin
ANS: Vitamin folic acid
Folic acid is associated with the metabolism of histidine .
Formimino glutamate (FIGLU) formed histidine metabolism
accumulates and is excreted in urine. Histidine load test utilizing
the excretion of FIGLU in urine is used to access folic acid
deficiency.

5.Specific disease caused by vit.B1 deficiency1.Pellagra

2.angular cheilitis
3.Megaloblastic anemia
4.Peripheral polyneuritis
ANS :Peripheral polyneuritis
Thiamine pyrophosphate which is a co-enzyme of B1 plays an important role in
transmission of nerve impulse.
6.Pernicious anemia occurs in deficiency of1.Vit.B1
2.Vit.B12
3.Vit C
4.Vit.D
ANS :Vit. B12
Schilling test is used to detect B12 deficiency.
7.Rhodopsin deficiency is chiefly associated with1.Vit.D
2.Rickets
3.Vit.A
4.Scurvy
ANS : Vit.A
Rhodopsin is a conjugated protein present in rods .It contains 11-cis-retinal
which is one of the vitamer of vit.A.

8.Deficiency of which vitamin caused glossitis ,dementia ,roughed keratotic areas on skin
and gastrointestinal symptom?
1.Riboflavin
2.Pyridoxine
3.Niacin
4.Pantothenic acid
ANS :Niacin
Niacin deficiency results in pellagra a condition manifested as dermatitis ,diarrhoea
,dementia.
9.Peripheral neuropathy due to deficiency of vit.is seen with1.Pyridoxine
2.Vit.E
3.Vit.A
4.Pantothenic acid
ANS :Pyridoxine
Peripheral neuropathy is seen in deficiency of vit.B1,B6,B12.
10.Vit.K deficiency is indicated by1.Low platelet count
2.Increased prothrombin time
3.Decreased prothrombin time 4.None
ANS :Increased prothrombin time
It is due to deficiency of clotting factor .
11.Consumption of raw egg white in the diet may result in the deficiency of1.Riboflavin
2.Biotin
3.Thiamin
4.Pyridoxine
ANS:Biotin
Biotinis called as anti-egg white injury factor.

12.The reaction inhibited in thiamine deficiency is1.Pyruvate to acetyl co A.

2.Citrate to alpha keto glutarate.
3.Succinyl co A to fumarate.
4.None.
ANS: Pyruvate to acetyl co A
The conversion of pyruvate to acetyl coAis catalysed bypyruvate dehydrogenase.This reaction is
dependent on TPP.
13.Thiamine deficiency can be diagnosed by measuring1.Thiamine level in blood.
2.Alkaline phosphate level in blood.
3.Transketalase activity in RBC.
4.Plasma pyruvate and lctic acid levels.
ANS: 3.Transketalase activity in RBC
14.All of the following are true about manifestation of vit.E deficiency ,except1.Homolytic anemia
2.Posterior column abnormalities
3.Cerebellar ataxia
4.Autonomic dysfunction
ANS: Autonomic dysfunction
15.Aniacinosis results in1.Perleche
2.Beri-Beri
3.Pellagra
4.Nyctalopia
ANS:Pellagra
Aniacinosis is deficiency of niacin.

16.Thiamin deficiency causes decreased energy production because1.It is required for the process of transamination.
2.It is co-factor in oxidative reduction.
3.It is co-enzyme for transketolase in pentose phosphate pathway.
4.It is co-enzyme for pyruvate dehydrogenase.
ANS :It is co-enzyme for pyruvate dehydrogenase.
The co-enzyme thiamine pyrophosphate is intimately connected with the
energy releasing reactions in the carbohydrate metabolism.
17.First clinical sign of vit.A deficiency is1.Night blindness
2.Bitots spot
3.Xerostomia
4.Conjunctival xeroses
ANS: Conjunctival xeroses.
It is the first clinical sign of vit.A deficiency.
18.The 3-DS are seen in deficiency of1.Thiamine
2.Riboflavin
3.Niacin
4.Pyridoxine
ANS :Niacin
Niacin deficiency results in pellagra a condition manifested by 3-DS.

19.What are the early symptoms of hypervitaminosis D?

1.Thirst
2.Vomiting
3.Constipation
4.All
ANS:All
It occurs due to extremely large amount of vit.D intake.
20.William syndrome is associated with which vitamin?
1.Vit.A.
2.Vit.B
3.Vit.C
4.Vit.D
ANS:Vit.D
William syndrome occurs due to over dose of vit.D.