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REMEDIES IN TABLET
MANUFACTURING &
COATING
NADANASABAPATHI.P.,
M.Pharm
Jr.Research.asst
APEX LABORATORIES,
CHENNAI.
Problem in tablets are either related to
imperfections in any one or more of the
following factors:
I. Tableting Process
II. Excipient
III. Machine
Process related problems :
• CAPPING: It is due air-entrapment in the
granular material.
• LAMINATION: It is due air-entrapment in
the granular material.
• CRACKING: It is due to rapid expansion of
tablets when deep concave punches are
used.
Excipient related problems :
• CHIPPING: It is due to very dry granules.
• STICKING: It is due to excess moisture
presnt in the granules.
• PICKING: It is due the improper dring of
the granules.
• BINDING: It is due the excessive binder
present in the granules.
Machine related problems :
1. Large amount of fines in the Remove some or all fines through 100 to 200 mesh
granulation screen
2. Too dry or very low moisture Moisten the granules suitably. Add hygroscopic
content (leading to loss of substance e.g.: sorbitol, methyl- cellulose or PEG-
proper binding action). 4000.
3. Lower punch remains below the Make proper setting of lower punch
face of die during ejection. during ejection.
1. Granules not dried Dry the granules properly. Make moisture analysis
properly. to determine limits.
2. Too little or improper Increase or change lubricant.
lubrication.
3. Low melting point substances, Add high melting-point materials. Use high
may soften from the heat of meting point lubricants.
compression and lead to picking.
4. Low melting point medicament in Refrigerate granules and the entire tablet
high concentration. press.
5. Too warm granules when Compress at room temperature. Cool
compressing. sufficiently before compression.
6. Too much amount of binder. Reduce the amount of binder, change the
type or use dry binders.
PICKING RELATED TO MACHINE (DIES,
PUNCHES AND TABLET PRESS)
Sr.No CAUSES REMEDIES
1. Free rotation of either -Use keying in tooling, i.e. inset a key alongside
upper punch or lower of the punch, so that it fits the punch and
punch during ejection of a prevents punch rotation.
tablet.
-Newer presses have anti-turning devices,
which prevent punch rotation.