Thediagnostic accuracyofspectraldomainoptical coherence

tomographyfor neovascularagerelatedmacular degeneration:a

comparisonwith fundusuorescein
angiography
CWilde,MPatel,ALakshmanan, RAmankwah,SDhar
Munshiand WAmoaku
Represented by : monika

AMD

25
%
>7
5

Invasive Procedure
Patientshavetobe cannulated poor
venousaccess
Facilitiesforresuscitation beavailable
Time-consuming,
Thequalityofthe images operatordependent
Inconvenient
Unnecessary beforecommencingtherapywithantiVEGFtherapies

Material and Methods

Retrospec
tive
SD-OCT,
FP,and
FFA 411
patiens

KingsMillHospital,
Sutton-in-Asheld
February2009toFebruar
y2013

231
(CNV)
27 classic no
occult
16 predominantly
classic
50 minimal classic
129 occult
9 peripapillary

47
(FALSE)
7 disciform scars
40 PED,IRF, SRF,
Retinal thickening

Discussion
SD-OCT is increasingly used in clinical
practice for the follow-up of patients
undergoing treatment with anti-VEGF in
nAMD and other retinal vascular
disease.
It provides a time efficient, noninvasive
imaging tool that allows high-resolution,
pseudohistological cross-sectional
images of the retina, RPE, and choroid.

 This study confirms that SD-OCT in

comparison to the reference standard of nonstereoscopic FFA is highly sensitive (100%) at
detecting newly presenting nAMD
Sandhu etal reportedthesensitivitywithTDOCTalonetobe 96.4%.
TheuseofTD-OCT has been reported by
others to fail frequently in the detection of
abnormalities that are associated with
uorescein leakage from CNVonFFA
afewstudieshavedemonstratedSD-OCT to
be more sensitive at detecting abnormalities
associated with nAMDthanTD-OCT

 Another recent publication investigating

new patients referred for suspected wet
AMD also reported a sensitivity of 100%.
The AMD Doc Study reported a
sensitivity of 69% in the detection of
conversion to nAMD in high risk eyes.
In 5% of eyes in our study no SRF or IRF
was present on SDOCT, yet FFA
demonstrated an occult lesion.
In all of these cases SD-OCT
demonstrated a PED.

 The Topcon 3D OCT 1000 (Topcon) used in

this study can image an area of 8.2mm
which would have included both the disc
and the macular area and may have
prevented this grading error.
The high false-positive rate in the present
study represents the difficulty in correctly
identifying areas of hyper-reectivity on
SD-OCT that represent active CNV, and
distinguishing them from those that
represent inactive gliosis, particularly in
the setting of chronic lesions.

CONCLUSION

TITLE

Too long / short ?

No

Illustrate the
observed variables ?

Yes

Non standard
Abbreviation?

None

Any corresponding
author and email ?

Author : WM Amoaku
E-mail :
winfried.amoaku@nottingha
m.ac.uk

ABSTRACT

Consists of 4 parts:
background, method,
result, and conclusion
?

Yes

Any keywords ?

Yes

Is the abstract wholly

appropriate?

Yes

AIM & BENEFIT OF THE RESEARCH

Does the aim
explained ?
Does the benet
explained ?

Yes
Yes

METHODS
Is there any research
design ?

Yes

Population & samples

Yes, it is explained

Inclusion-Exclusion
Criteria

Yes

Sampling & Sample

size formulation

No

Treatment

No

METHODS
Is there any bias on
procedure, means,
and subject
obedience ?
Is there any
operational denition
?
Is there any ethical
clearance consent ?
Data analysis ?

Yes

No
Yes
No

RESULTS
Any Drop out ?
Is there any
subject
characteristic
table ?
Is there any aim
for the results?

Yes
No

Yes

SD-OCT in comparison to nonstereoscopic FFA is highly

What is the main
sensitive at detecting newly
result of the
presenting nAMD but cannot
research ?
replace FFA in the diagnosis of
nAMD in current clinical practice
DISCUSSION
Did the result
Yes
suits the theory ?
Is there any

CONCLUSION
Could it be
applied in
chosen sample,
reachable and
target
population ?

Yes

Could this
research be
applied for
patients ?

Applicable

Mohon Bimbingan dan Saran