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PENANGANAN INFERTILITAS
PADA PRIA
ALVARINO
SIE UROLOGI
LAB ILMU BEDAH
FK. Univ. ANDALAS
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PENDAHULUAN
1/3
1/3
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FISIOLOGI REPRODUKSI
PRIA
HYPOTHALAMUS-PITUITARY-GONADAL AXIS ( HPG )
EMBRYO PHENOTYPE
SEXUAL MATURATION
ENDOCRINE TESTICULAR FUNCTION
testosterone
EXOCRINE TESTICULAR FUNCTION
spermatogenesis
ORGAN REPRODUKSI
PRIA
TESTIS
ENDOCRINE
LEYDIG CELL TESTOSTERON, 2%
(FREE), 44%TeBG/SHBG, 54%Albumin.
TeBG INCREASED LEVEL OF ESTROGEN
& THYROID , SH , GH , Obesitas.
EXOCRINE
SERTOLI CELL Maturation 85-90%
vol.testis.
SPERMATOGENESIS
SPERMATOGONIA
SPERMATOZOA
13 STAGES
74 DAYS
ETIOLOGI
PRE TESTICULAR :
HIPOTALAMUS
Endokrinopati
Sexual dysfunction
HIPOFISIS
. Malignancy,radiation ,operation
. Hiperprolaktinemia,hemokromatosis
TESTICULAR
UDT
CHROMOSOMAL ABNORMALITY
INFECTION
MEDICATION
INJURY
VARICOCELE 20-40%
POST TESTICULAR :
IDIOPATHIC 40%
History of infertility
Medical hystory
Gonadotoxin
DURATION
PRIOR PREGNANCIES
PRESENT PARTNER
PREVIOUS TREATMENT
EVALUATION & TREATMENT OF
WIFE
Chemicals / pestisides
Drugs (chemo,
cimetidine
Sulfasalazine,
Nitrofurantoin,
Smoking, Alcohol
Marijuana, Androgen
steroids
Thermal exposure
Radiation
Sexual Hstory
Surgical History
Family history
POTENCY
LUBRICANTS
TIMING
FREQUENCY
ORCHIECTOMY
RETROPERITONEAL, PELVIC
INJURY
PELVIC, INGUINAL, SCROTAL
SURGERY
HERNIORRAPHY
Y-V PLASTY, TUR-P
CYSTIC FIBROSIS
ANDROGEN RECEPTOR
DEFICIENCY
INFERTILE FIRST DEGREE
RELATIVES
Infection
Review of System
UDT, ORCHIOPEXY
HERNIORRAPHY
Y-V PLASTY
TESTICULAR TORSION
TERSTICULAR TRAUMA
ONSET OF PUBERTY
VIRAL, FEBRILE
MUMPS ORCHITIS
VENEREAL DISEASE
TUBERCULOSIS, SMALLPOX
RESPIRATORY INFECTIONS
ANOSMIA
GALACTORRHEA
IMPAIRMENT VISUAL FIELDS
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PEMERIKSAAN FISIK
Pemeriksaan genital eksterna : Testis,
epididymis, Vas deferens,
varicocele,genital kecil
Karakteristik seks sekunder ;
penyebaran rambut ketiak,pubis dan
badan tumbuh besar.
Abnormal ;
anosmia(Kallmann),galaktore,
ggn lap.penglihatan,gynekomastia. 10
PEMERIKSAAN AWAL
Urinalysis
Semen analyses
Hormonal evaluation
(LH, FSH, Testosteron, Prolactine )
less then 3% showed abnormalities
Indications : < 10 million/ml, sugest
endocrinopathy
Azoospermia + (n) FSH Vasography &
biopsy
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KARAKTERISTIK SPERMA
NORMAL
Volume 1,5 - 5 ml
Conc > 20 million/ml,
total > 50 million
Motile > 50%
Motile grade >2
normal morphology
>30-50%
Fructose +
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HORMONE PROFILE
CONDITION
FSH
LH
PRL
NORMAL
NL
NL
NL
NL
PRIMARYTESTIS FAILURE
LO
HG
NL/HG NL
Hypogonadotrophic-hypogonadism
LO
LO
LO
LO
LO/NL LO
HG
HG
HYPERPROLACTINEMIA
HIGH
ANDROGEN RESISTANCE
HG
NL
NL
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PEMERIKSAAN TAMBAHAN
Semen leukocyte analysis
Antisperm antibody test
Computerized assisted semen analyses (CASA)
Hypoosmotic swelling test
Sperm penetration assay
Sperm-cervical Mucus interaction
ROS (reactive oxygen species)
GENETIC EVALUATION
Chromosomal study
Cystic fibrosis mutation testing
Y chromosome microdeletion analysis
POTENTIALLY
TREATABLE
UNTREATABLE
Varicocele
Obstruction
Infection
Ejaculatory
Dysfunction
HypogonadotropicHypogonadism
Immunologic Problem
Erectilel Dysfunction
Hyperprolactinemia
Idiopathic
Cryptorchidism
Vasal Agenesis
Bilateral Anorchia
Germinal Cell-Aplasia
Primary TesticularFailure
ChromosomalAnomalies
Immotile CiliaSyndrome
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PENATALAKSANAAN
SEMEN ANALYSIS
HISTORY
HORMONES
SURGICAL
THERAPY
NON
SURGICAL
TREATMENT
PHYSICAL
ADJUNCTIVE
TEST
ASSISTED
REPRODUCTIVE
TECHNIQUE
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HYPOGONADOTROPHICHYPOGONADISM
INCIDENCE ; LOW
ACQUIRED / CONGENITAL (KALLMANNIS SYNDROME)
DUE TO DECREASED PRODUCTION OF GnRH
ASSOCIATED WITH OTHER CONG ANOMALY : ANOSMIA,
DEAFNESS, CLEFT PALATE, RENAL ANOMALIES
ACQUIRED : PITUITARY TUMOR/TRAUMA, ISOLATED
GONADOTROPIN DEFICIENCY, ANABOLIC STEROID USE.
DIAGNOSTIC TEST : CT / MRI RULE OUT TUMOR
THERAPY : hCG 1500-3000 IU sC 3 times weekly for 8-12
weeks, then hMG 37,5-150 IU sC 2-4 times weekly
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HYPERPROLACTINEMIA
INCIDENCE ; LOW
HYPERPROLACTINEMIA NEG FEEDBACK TO GnRH,
INHIBITORY EFFECT on LH BINDING to LEYDIG
INFERTILITY, ERECTILE DYSFUNCTION
ETIOLOGY : HIPOPHYSEAL TUMOR, HYPOTHYROIDSM,
LIVER DISEASE, DRUGS (Phenothiazine, Tricyclic
Antidepresant, some antihypertensive)
DIAGNOSTIC TEST : CT/MRI RULE OUT TUMOR
THERAPY :
CAUSAL or
BROMOCRIPTINE 2,5 -7,5 mg 2-4 TIMES DAILY
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INCIDENCE : RARE
DEFICIENCY OF ADRENAL HYDROXYLASE DECREASED
CORTISOL SECRETION INCREASED ACTH
INCREASED ADRENAL ANDROGEN PRODUCTION
DECREASED Gnrh SUPPRESSES SPERMATOGENESIS.
DIAGNOSTIC TEST : Urinary 17-KETOSTEROID or
DEHYDROEPIANDROSTERON (DHEA)
THERAPY : GLUCOCORTICOID REPLACEMENT.
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IMUNOLOGIC INFERTILITY
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EFECT of GTI
ABNORMAL SEMEN QUALITY < 2%
Severe (Enterobacteriaceae, Chlamydia, Gonorrhoeae)
TESTIS ATROPHY / EPIDIDYMAL DUCT OBSTRUCTION
generate ROS harm sperms ability to fertilize
Therapy ; Antibiotics
Persistent Obstruction Surgery
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RETROGRADE EJACULATION
ETIOLOGY :
ANATOMIC,
: BLDDER NECK SURGERY
NEUROGENIC, : SPINAL CORD INJURY, RETROPERTONEAL
SURGERY, DIABETES MELITUS
PHARMACOLOGIC
: NEUROLEPTICS, TRICYCLIC
ANTIDEPRESSANT, ALPHA BLOCKERS, ANTIHYPERTENSIVE
IDIOPATHIC
THERAPY :
ALPHA ADRENERGICS AGONIST (EPHEDRINE,
PSEUDOEPHEDRINE, IMIPRAMINE, PHENYLPROPANOLAMINE
ART INTRAUTERINE INSEMINATION
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ANEJACULATION
INCIDENCE : RARE
ETIOLOGY :
NEUROGENIC, : SPINAL CORD INJURY, RETROPERTONEAL
SURGERY, DIABETES MELITUS, TRANSVERSE MYELITIS,
MULTIPLE SCLEROSIS
PSYCHOGENIC / IDIOPATHIC
THERAPY :
RECTAL PROBE EJACULATION
PENILE VIBRATORY STIMULATION
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ERECTILE DYSFUNCTION
???
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EMPIRIC THERAPY
TAMOXIFEN
ANDROGENS
TESTOSTERON REBOUND
AROMATASE INHIBITORS
GONADOTROPINS
GnRH
KALLIKREINS
PROSTAGLANDIN SYNTHETASE INHIBITORS
BROMOCRIPTINE
PENTOXIFYLLINE
ANTIOXIDANTS
CARNITINE.
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ANTIOXIDANT
EMPIRIC THERAPY
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PEMBEDAHAN
Varicocelectomy
Vasovasostomy,
Epididymovasostomy, TUR of
Ejaculatory duct
Ablation of Pituitary Adenoma
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PROPILAKSIS PEMBEDAHAN
Orchydopexy
Operation for Testicular Torsion
Electroejaculation
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ASSISTED REPRODUCTIVE
TECHNIQUES
If neither Surgery nor medical therapy is
apropriate A logical treatment, technique
atempt to overcome the problems of reduced
sperm motility and number is ART
Sperm Donation :
Husband or Others
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INTRAUTERINE INSEMINATION
INDICATION ;
BY PASS CERVICAL FACTORS
IMUNOLOGIC INFERTILITY
LOW SPERM QUALITY
MECHANICAL PROBLEM OF SPERM DELIVERY
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ICSI
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MALE
CONTRACEPTIV
E
35
METHODE
ESTABLISHED
CONDOM
PERCUTANEOUS VAS OCCLUSION
TRADITIONAL VASECTOMY
NON-SCALPEL VASECTOMY
RESEARCH
VASECTOMY
MINOR SURGICAL PROCEDURE
CUTTING / OCCLUSSION OF VAS
DEFERENS
MINOR COMPLICCATION
NO CHANGES IN SEXUAL
FUNCTION
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Syarat Operasional
Vasektomi
1. Ruang tunggu
2. Ruang pendaftaran
3. Ruang periksa
4. Ruang ganti pakaian
5. Ruang bedah
6. Ruang rawatan paska bedah
7. Laboratorium sederhana
8. Ruang peralatan dan pencucian alat
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Pelaksana pelayanan
Vasektomi
40
Peranan dokter
1. Menseleksi calon akseptor
2. Melakukan pembedahan
3. Pelayanan paska bedah
4. Mengkoordinasi semua kegiatan
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Peranan paramedik
1. Menerima dan mencatat akseptor
2. Mempersiapkan calon
3. Memantau keadaan akseptor
selama dan setelah operasi
4. Mempertsiapkan segala sesuatu
kebutuhan dokter sebelum dan saat
tindakan
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Syarat Akseptor
1. Sukarela
2. Bahagia
3. Kesehatan
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Pemeriksaan prabedah
1. Anamnesa
2. Pemeriksaan fisik
3. Pemeriksaan laboratorium
sederhana
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VASECTOMY
PREPARATION :
SHAVE AND WASH THE SCROTUM
BRING A PAIR OF TIGHT FITTING
UNDERWEAR OR ATHLETIC SUPPORT
AVOID ANTI INFLAMATORY DRUGS
( IBUPROFEN, ASPIRIN BEFORE
SURGERY
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Alat emergensi
1. Oksigen
2. Alat resusitasi sederhana
3. Obat2an
4. Infus set
5. Spuit 5 dan 10cc
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Komplikasi premedikasi
1. Intoksikasi Hentikan obat
2. Kejang2 -- Valium 5-10mg IV
3. Alergi ----- Dexamethason 5
mgIV
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Teknik Vasektomi
1.Celana dibuka dan pasien
berbaring
2.Bersihkan daerah operasi
3.Tutup dengan kain steril
berlobang
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VASEKTOMI
TANPA PISAU
PROCEDURE
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KOMPLIKASI
HAEMATOM
PERDARAHAN
ANTI BODI SPERMA
GRANULOMA SPERMA
INFEKSI
REKANALISASI
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KEGAGALAN VASEKTOMI
1.Spermatozoa ditemukan setelah 3
bulan atau setelah 10-12 kali
ejakulasi
2. Ditemukan spermatozoa setelah
sebelumnya azoosperma
3. Pasangannya hamil setelah
berhubungan dg akseptor 3 bulan
paska vasektomi
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Nasehat
Perawatan luka yang baik
Ada komplikasi kembali ke RS
Obat2an
Jangan kerja berat/naik sepeda dulu
Boleh berhubungan suami
istri,sebaiknya pakai alat pencegah
kehamilan dulu selama masih ada
sisa sperma
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Catatan medik
1.Identitas peserta dan istri
2.Pemeriksaan pra bedah
3.Laporan pembedahan
4.Data paska bedah
5.Data kunjungan ulang
6.Laporan komplikasi dan kematian
7.Laporan tertulis permohonan dan
persetujuan kontrasepsi mantap.
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