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Lecture Outline
Dentifrices
Ideal requirements for dentifrices
Dentifrices contents
Recent development in toothpaste
Mouthwash
Lecture Outcomes
Upon completion of this course students
would be able to
Discuss different methods of chemical plaque
control
Components of toothpaste and mouthwash
Methods of Plaque
Control:
Mechanical Plaque Control Methods.
Chemical Plaque Control Methods.
TOOTHPASTE /
DENTIFRICES
PURPOSE
Cleaning
Polishing
Removal of stains
Reduce incidence of tooth decay
Ideal requisites
Should decrease plaque & gingivitis
Prevent pathogenic growth
Should prevent development of resistant bacteria
Should be biocompatible
Should not stain teeth or alter taste
Should have good retentive properties
Should be economic
Toothpaste Contents
Abrasives (20%-40%)
Binders (2%)
Humectants (20%-40%)
Detergents (1%-2%)
Flavoring agent (2%)
Sweetening agents (2%)
Colouring agent (2%)
Preservatives (<1%)
Water (20%-40%)
Abrasive
Functions of Abrasive
Also called as polishing agent
Solid, insoluble particles
Removes debris and residual strain from teeth
Mild abrasive action
Removes stained pellicle, restores natural luster,
enhances enamel whiteness
Examples of Abrasives:
Aluminium oxide
Calcium pyrophosphate
Carbonates like sodium bicarbonate, calcium carbonate
silicas
Binde
rs
Functions of Binder
To provide consistency and shape.
Keep the solid phase properly suspended in the liquid phase .
Prevent the toothpaste from drying out.
Contribute to the creamy consistency of the toothpaste and
Examples of Binders:
Humecta
nts
Functions of humectants
Used in toothpaste to prevent loss of water and
Examples:
Glycerine
Sorbitol
Polyethylene glycol
Mannitol
Propylene glycol
Detergents/
surfactants
Function
Produce foam and aid in the removal of
debris.
Emulsifies flavoring agents.
Antimicrobial property
High level may cause mucosal irritation.
May react with other toothpaste components.
Examples:
Sodium Lauryl Sulfate
Sodium N-Lauryl Sarcosinate
Polyethylene glycol (PEG)
Sweeteners and
Flavors
Functions
Render the product pleasant to use & leaves a
fresh taste in mouth after use
Sweeteners: sodium saccharin, sorbitol,
mannitol, xylitol
Flavors: improve taste of toothpaste
Examples
peppermint,
spearmint,
wintergreen,
menthol,
cinnamon
Preservatives and
Solvents
Function of Preservatives:
prevent the growth of micro organisms such as mold and
Examples:
alcohols,
sodium benzoate,
dichlorinated phenols
Function of Solvents:
dissolves the ingredients and allows them to be mixed.
Water is the most common solvent used.
Fluoride
Function:
Increases resistance to enamel solubility.
Restricted usage level (for adults it must be within
Examples:
Sodium fluoride
Sodium monofluorophosphate
Stannous fluoride
Therapeutic
Agents
Anti-caries agents:
sodium fluoride and sodium monofluorophosphate
Anti-plaque:
Sodium Lauryl Sulphate, Triclosane, Zinc and Stannous ions
Anticalculus agents (crystal growth inhibitors)
Pyrophosphate, Zn citrate, Zn chloride
Desensitizing agents
Sodium fluoride, potassium nitrate
Anti-dentin hypersensitivity:
Potassium salts
Whitening agents:
Papain, Dimethicone
Anti bacterial agents
Triclosan, delmopinol, metallic ions & Zn-citrate trihydrate
Recent developments in
dentifrices
TRICLOSAN
Phenol derivative
Is synthetic and ionic
Used as a topical antimicrobial agent
Broad spectrum of action including both gram
positive and gram negative bacteria
It also includes mycobacterium spores and
Candida species
MECHANISM OF ACTION
TRICLOSAN
BACTERIOLYSIS
Triclosan
Triclosan is included in tooth paste to reduce
plaque formation
Used along with Zinc citrate or co-polymer
Gantrez to enhance its retention within the
oral cavity
Triclosan delay plaque formation
It inhibits formation of prostaglandins &
leukotrienes there by reduces the chance of
inflammation
METALLIC IONS
eg:
Zn & Cu ions
MECHANISM OF ACTION
It reduces the glycolytic activity in bacteria
QUARTERNARY AMMONIUM
COMPOUNDS
Cationic antiseptics & surface active
agents
Effective against gram positive organisms
MECHANISM OF ACTION
Positively charged molecule reacts with
negatively
charged
cell
membrane
phosphates and thereby disrupts the
bacterial cell wall structure
Eg: Benzanthonium chloride,
Benzalleonium
cetylpyredinium
chloride and
SANGUINARINE
It is a benzophenanthredine alkaloid
It is most effective against gram ve
organisms
ANTIBIOTICS
Vancomycin, erythromycin, Natamycin and
Kanamycin
Due to bacterial resistance problems the
use of antibiotics has been reduced
CHLORHEXIDINE
GLUCONATE(0.2%)
It is a cationic bisbiguanide
Effective against gram +ve, gram ve
MECHANISM OF
ACTION
Antiplaque action of chlorhexidine
Bacteriocidal action
increased concentration of chlorhexidine
Progressive greater damage to membrane
Larger molecular weight compounds lost
Coagulation and precipitation of cytoplasm
Free CHX molecule enter the cell & coagulates
proteins
Vital cell activity ceases
cell death
ADVERSE EFFECTS OF
CHLORHEXIDINE
Brownish staining of tooth or restorations
Loss of taste sensation
Rarely hypersensitivity to chlorhexidine
Enzymes
Enzymes has been used as active agents
in antiplaque preparations
It is due to the fact that enzymes would be
able to breakdown already formed matrix
some plaques and calculus
Some are proteolytic and have bactericidal
action
eg:Mucinase, mutanase, dextranase etc
DELMOPINOL
Inhibits plaque growth and reduces gingivitis
Mechanism of action
Interfere with plaque matrix formation & also reduces
bacterial adherence
It causes weak binding of plaque to tooth, thus aiding
in easy removal of plaque by mechanical procedures
It is therefore indicated as a pre brushing mouth
rinse
Adverse effect of
delmopinol
Staining of tooth & tongue
Taste disturbances
Mucosal soreness & erosion
35%
Essential Oil Preparation Contains:
Thymol
Eucalyptol
Menthol
Methyl Salicylate
Alcohol (up to 24% depending on the preparation)
Questions