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group systems
History.
serum
cells
1
Antigens on
Antibody in
phenotype
A
B
AB
O
RBCs
A
B
AB
none
serum
Anti-B
Anti-A
None
Anti-A,B
A Antigen
-1,2
-1,3
-1,4
D-galactose
-1,3
N-acetylglucosamine
-1,3
N-acetyl-D-galactosamine
L-fucose
A gene produces an
enzyme which adds the
A specific sugar NAcGal
B Antigen
-1,2
-1,3
-1,4
D-galactose
-1,3
N-acetylglucosamine
-1,3
N-acetyl-D-galactosamine
L-fucose
B gene produces an
enzyme which adds the
B specific sugar D-Gal
A
B
AB
AB
OO
Inheritance.
A
A O
A B
AB
A O
A
B
B O
B O
B
Phenotype
Genotype
O O
O
Genotype
Phenotype
Anti-A
Anti-B
A1
Red Cells
A2
Red Cells
B
Red Cells
O
Red Cells
AB
Antibodies
Naturally occurring
Predominantly complement binding IgM.
Low levels of IgG
Can cause:
Immediate and severe Haemolytic
Transfusion Reactions;
Mild to moderate Haemolytic Disease of
the Newborn
Transfusion practice
Identical ABO phenotype blood is best match but
where not available, use ABO-compatible blood
group O cells are universal donors
group AB - universal recipients
Recipient
phenotype
A
B
AB
O
History
1939 Levine and Stetson
Severely anaemic mother
Hydropic
newborn
Severe
HTR
Husband ABO
compatible
History
RBCs
Genetics
chromosome1
2 genes RHD and RHCE codominant
protein antigens
4 alleles can occupy RHCE locus
RHce, RHcE, RHCE, RHCe
Inheritance of RHD = RhD positive
D ve individuals inherit only RHCE
there is no d antigen
inheritance.
R1r
DCeDcE
DCcEe
R1R2
R2r
DCce
DCedce
DcEe
DcEdce
DCedce
DCe
dceDcE
DcEe
R1R1
R2r
Phenotype
Genotype
dce dce
ce
rr
Genotype
Phenotype
The D Antigen.
Antibodies
Predominantly IgG occasional IgM anti-E
Delayed Haemolytic Transfusion Reactions
Extravascular haemolysis
Haemolytic Disease of the foetus and
newborn
Warm Auto immune Haemolytic anaemia
Plasma Membrane
fluid mosaic model describes
sea of lipids in which proteins float like
icebergs
50 % lipid & 50 % protein
held together by hydrogen bonds
lipid is barrier to entry or exit of polar
substances
proteins -gatekeepers -- regulate traffic
50 lipid molecules for each protein molecule
Membrane Fluidity
Membranes are fluid structures, most
of the lipids and many of the
proteins easily move in the bilayer.
Membrane lipids and proteins are
mobile in their own half of bilayer.
Cholesterol serves to stabilize
membrane and reduce fluidity.
Membrane Proteins
Integral Proteins
many are glycoproteins.
combined glycoproteins and glycolipids
form the glycocalyx
cell recognition
Adherence
protection from digestion by enzymes
in extracellular fluid.
Functions of Membrane
Proteins
Formation of Channel
passageway to allow specific substance to
pass through
Transporter Proteins
bind a specific substance, change their
shape & move it across membrane
Receptor Proteins
cellular recognition sitebind to substance
Enzymes
Functions of Membrane
Proteins
Cell Identity Marker
allow cell to recognize
other similar cells
Linker
anchor proteins in cell
membrane or to other cells
allow cell movement
cell shape & structure
Chimkupete
Blood
Definition
Properties
Composition
Plasma
Cells
Circulation
arteries, veins
Functions
CFU-E
CFU-Meg
Proerythroblast Megakaryoblast
Reticulocyte
CFU-GM
Eosinophilic
& Basophilic
myeloblastMyeloblast
Monoblast
megakaryocyte
Eosinophil
Erythrocyte
Platelets
Basophil
Neutrophil Monocyte
Macrophage
T lymphocyte
Plasma cell
B lymhocyte
Blood cells
Numbers
Morphology
Formation
Maturation
Functions
Lymphocytes &
monocytes
Morphology
Maturation
Functions