Documenti di Didattica
Documenti di Professioni
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Rassoul Dinarvand
Professor of Pharmaceutics
Pharmaceutics 5
Chemical engineering
Pharmaceutical engineering
Particle engineering
Solid lipid particles
Dendrimers
Mechanical engineering
Mechanical pumps
Pharmaceutics 5
Pharmaceutics 5
Reservoir devices
-
Pharmaceutics 5
Biodegradable polymers
-
Simple release mechanism, but difficult to obtain fine control over degradation
Poly(lactide-co-glycolide) (PLGA)
Examples in use
-
Resomer (PLGA)
Vicryl (PLGA)
Pharmaceutics 5
Hydrogels
] [
O
O
OH
O
O
HEMA
>95 parts
polymerise
O HO
O
O
O
O
OH O
Monomer (water-soluble)
Cross-linker
Hydrogel
Pharmaceutics 5
Mucoadhesives
] [
O
OH
O
n
Methacrylic acid
(MAA)
Poly(ethyleneglycol)
dimethacrylate
PEGDMA
polymerise
HO
OH
Adhesive
groups
O
O
[
Pharmaceutics 5
Type of polymer
Non-degradable / Degradable
Type of Design
Reservoir
Matrix
Release mechanisms
Diffusion / polymer degradation / combination
Pharmaceutics 5
Pharmaceutics 5
10
Drug delivery from (a) reservoir and (b) matrix swelling-controlled release systems
Pharmaceutics 5
11
Pharmaceutics 5
12
Molecular gates for the delivery of insulin triggered by the presence of glucose
in the bloodstream
Pharmaceutics 5
13
Drug delivery from (a) bulk-eroding and (b) surface-eroding biodegradable systems
Pharmaceutics 5
14
Particulate
systems
Nanoparticles
Nanocapsules
Nanospheres
Microparticles
Microspheres
Microcapsules
Pharmaceutics 5
15
Films
Membranes
Fibers
Rods
Beads
Discs
Cylinders
Pharmaceutics 5
16
Pharmaceutics 5
17
Diffusion
Concentration gradient in polymeric
matrix
Chemical reaction
Polymer biodegradation
Solvent effect
Release of soluble drugs in hydrogels
Mechanical release
Drug release from mechanical devices
such as pumps
Pharmaceutics 5
18
Implants
Injectables
Transdermal
Oral
Nasal
Ophthalmic
Vaginal
Pharmaceutics 5
19
Solid tumor
Apply magnetic
field to concentrate
particles
Modulate field to
release drug from
particles
Pharmaceutics 5
20