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HEMATOPOIESIS
Hematopoiesis merupakan proses pembuatan sel
darah
Berasal dari bahasa yunani haima (darah) dan poiein
(membuat). Rata rata untuk dewasa, sum-sum
tulang ~5x1011 sel per hari.
Sel dari darah dibagi menjadi erythrocytes (red blood
cells), leukocytes (white blood cells) berbagai macam,
dan platelets.
Erythrocytes : Erythropoiesis
Leukocytes : Leukopoiesis
Thrombocyte : Thrombopoiesis
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THE LOCATION OF
HEMATOPOIESIS
Hematopoiesis dimulai di yolk sac saat bulan
pertama dari embryogenesis tapi secara
perlahan berpindah ke hati dan, dengan jumlah
lebih sedikit, limfa.
Hati merupakan tempat hematopoiesis saat
trimester kedua.
Sum-sum tulang menjadi tempat hemopoiesis
utama setelah bulan ketujuh.
Setelah lahir, sum-sum tulang menjadi tempat
satu-satunya hematopoiesis (intramedullary
hematopoiesis).
Hematopoiesis may resume in the liver and
spleen after birth in conditions associated with
fibrosis of the bone marrow (extramedullary
NUTRITIONAL REQUIREMENT OF
ERYTHROPOIESIS
Vitamin B12
Folic acid
Vitamin B6
Trace Metals
Iron
Other Vitamins ( Vit C, Vit A,
Vit E)
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ERYTHROPOIESIS
The earliest recognizable RBC
precursor is proerythroblast,
The last nucleated RBC precursor is
the orthochro- matophilic
erythroblast, which is
characterized by wellhemoglobinized cytoplasm; the
nucleus is then lost, producing the
reticulocyte.
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ERITROPOESIS
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Proerythroblasts
the earliest, least mature cells in the
erythrocyte forming series
(erythropoiesis).
Proerythrocytes exist in circulating
blood only under pathological
conditions (extramedullary
hematopoiesis; breakdown of the
bloodbone marrow barrier by tumor
metastases, erythroleukemia)
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RETICULOCYTE
Reticulocytes mengandung
ribonucleic acid (RNA)
Normal value in peripheral blood
0,5 1,5 %
Cell size : Sedikit lebih besar
dari sel dewasa(7-9 )
Ukuran sel: Bundar
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RETICULOCYTE
Cytoplasma :fully hemoglobinized;
nucleus extruded from cell, leaving a
slightly polychromatic red cell when
by romanowsky (identified using
supravital stains such as new
methylene blue; BCB)
: Hemolytic anemia, acute
bleeding, th/ anemia
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ERYTHROCYTES
Cell size : 6,7-7,7
Cell shape : Round
Cytoplasm : Staining:
pink, with slightly
more intense color at
the peripheral and
lighter color in the
center
Nucleus : not present
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ERYTHROCYTES
Composition :
- 60% Air
- 28% hemoglobin :
* blood pigmen
* sarana transport O2
* 96% globin
* 4% heme
- 7% Fat
- Carbohydrat, Electrolyte, Enzyme,
Metabolite
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Ukuran Erythrocyte
1. Normal (normositer)
Aplastic anemia, acute
bleeding, hemolytic anemia
2. Micrositer Iron def
Anemia, ACD, thalasemia,
sideroblastic anemia
3. Macrositer Folic acid &
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Erythrocyte Form
Normal : biconcave
Abnormal : ovalocyte, spherocyte, stomatocyte, target
cells, ect
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Ovalocyte
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Target cells
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Stomatocyte
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Spherocyte
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Poikilocytosis
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