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ENDOCRINE SYSTEM
By Sawiji Amani
Mobile phone: 081 328 028333
E-mail: sawijiamani@gmail.com
Basic Sciences Department
Muhammadiyah Gombong University
Central Java Indonesia
Figure 3a:
Hormones
SECTION 1: INTRODUCTION
I. Organization of Endocrine System
The functions of the body are regulated by the
nervous and the endocrine system.
The endocrine system consists of endocrine
glands and cells that secrete hormones in
various tissues.
A hormone
--chemical substance
--is secreted into the internal body fluids by
one specialized cell or a group of cells and
--has a physiological control effect on other
cells of the body.
Nervous system
The nervous system exerts
point-to-point control through
nerves, similar to sending
messages by conventional
telephone.
Nervous control is electrical in
nature and fast.
Transportation of Hormones
2, Neuroendocrine:
neurons secrete
substances
(neurohormones) that
reach the circulating
blood and influence the
function of cells at
another location of the
body.
Transportation of Hormones
3. Paracrine, in which cells secret substances
that diffuse into the extracellular fluid and affect
neighboring cells.
2. Signal Transmission
The role of the hormones is to transit the
regulatory signals from the control (endocrine)
system to the target cells (organs or glands).
It could enhance or inhibit some function of the
target.
Signal
amplification
during the
transmembrane
and
intracellular
transmission
SECTION 2:
THE PITUITARY HORMONES
AND THEIR CONTROL
BY THE HYPOTHALAMUS
I. Anatomical and
Functional
Connection
Between the
Hypothalamus
and Pituitary
(hypothalamohypophyseal
portal system and
tract)
TSH, Thyroid
stimulating hormone
ACTH,
Adrenocorticotropin
hormone
FSH, Folliclestimulating hormone
LH, Luteinizing
hormone
MSH, Melanophorestimulating hormone
GH, Growth
Hormone;
PRL, Prolactin
4. Hormones Secreted
from the Posterior
Pituitary
vasopressin and
oxytocin
produced in neuron
cell bodies within the
supraoptic and
paraventricular nuclei
of the hypothalamus
transported to the posterior pituitary by nerve fibers of
the hypothalamo-hypophyseal tract.
1.Growth Hormone
(1)Physiological functions of growth hormone.
1) Growth effect
Growth hormone stimulates cell division, especially in
muscle and epiphyseal cartilage of long bones.
The result is muscular growth as well as linear growth.
Effect of
hypophysectomy
on growth of the
immature rhesus
monkey.
Both monkeys
were the same
size and weight 2
years previously,
when the one on
the left was
hypophysectomiz
ed.
If an acidophilic tumor
occur after adolescence
that is , after the epiphyses
of the lone bones have fused
with shafts
the person cannot grow
taller,
but the soft tissue can
continue to grow and the
bones can grow in
thickness.
This condition is known as
acromegaly.
Receptor
mechanism of the
growth hormone
effect
GH
somatomedins
(SM) also
called insulin-like
growth factor, IGF)
in the liver
growth of bone and
other peripheral
tissues.
2) Metabolic effects of GH
A, On Protein metabolism
Enhance amino acid transport to the interior of the
cells and increase RNA translation and nuclear
transcription of DNA to form mRNA, and so
increase rate of protein synthesis.
GH also reduces the breakdown of cell proteins by
decreasing catabolism of protein.
B, On fat metabolism
Cause release of fatty acids from adipose tissue and
then increasing the concentration of fatty acids.
Therefore, utilization of fat is used for providing
energy in preference to both carbohydrates and
proteins.
C. On glucose metabolism
Decreases cellular uptake of glucose and glucose
utilization,
leads to increase of the blood glucose concentration.
Hypothalamus
- SS
GRH +
Pituitary
GH
Liver
SM
Target tissues
2. Prolactin (PRL)
(1)Physiological function of PRL
1) On breast: stimulate the development and milk
secretion
In women, breasts development at puberty is
stimulated by estrogen, progesterone, growth
hormone, cortisol, insulin, thyroid hormones and
prolactin.
During pregnancy, great growth of breast tissues
occurs by stimulation of estrogen, progesterone and
prolactin but estrogen and progesterone inhibit the
secretion of milk.
PRF
Oxytocin secretion
Myoepithelial cells contraction
of mammary glands
Milk flows
PROLACTIN
SECRETION
(1)Roles of ADH
1) Antidiuretic effect (refer to chapter 8)
2) Pressure effect. High concentration of ADH have a
potent effect of constricting the arterioles
everywhere in the body, raise the resistance blood
flow and blood pressure
Vasopressin
Antidiuretic
hormone V2-receptor:
collecting duct
Vasopressor hormone V1-receptor:
vascular smooth muscle
OXYTOCIN
2) Effect on uterus
OXT powerful stimulate the smooth muscle
contraction, especially that towards the end of
gestation.
It is believed that OXT is at least partially responsible
for causing birth of the baby
SECTION 3:
THYROID GLAND
I. Functional
Anatomy
largest endocrine
glands in the body,
weighting about 20
25g.
Iodine
chain.
(MIT).
DIT
TSH
1. On Metabolism
(1) Calorigenic action of thyroid hormones
Thyroid hormones increase O2 consumption of most tissues in
the body, increasing heat production and BMR.
The mechanism of calorigenic effect of thyroid hormones may
be:
A: Enhances Na+-K+ ATPase activity
B: Causes the cell membrane of most cells to become leaky to
Na+ ions, which farther activates sodium pump and
increases heat production.
Hypothyroidism
2) On carbohydrate metabolism
A: Increase absorption of glucose from the
gastrointestinal tract
E: Enhance glycogenolysis, and even enhanced
diabetogenic effect of glucagon, cortisol and growth
hormone.
C: Enhancement of glucose utilization of peripheral
tissues.
3) On fat metabolism
Thyroid hormones accelerate the oxidation of free
fatty acids by cells and increase the effect of
catecholamine on decomposition of fat.
Thyroid hormones not only promote synthesis of
cholesterol but also increase decomposition of
cholesterol by liver cells.
The net effect of T3 and T4 is to decrease plasma
cholesterol concentration because the rate of synthesis
is less than that of decomposition.
The hypothyroid
individual is to have
fatigue, extreme
somnolence, poor
memory and slow
mentation.
(Inhibitory Protein)
HO
C=O
OH
HO
O
O
testosterone
cortisol
(1) On metabolism
1) On carbohydrate metabolism.
A, Stimulation of gluconeogenesis (formation of
carbohydrate from protein and other substances) by the
liver through two pathways.
----Cortisol activates DNA transcription in the liver cell nuclei
with formation of messenger RNAs that in turn lead to the
array of enzymes required for gluconeogenesis.
----The other is cortisol causes mobilization of amino acids
from extrahepatic tissues, mainly from muscle.
One of the effects of increased gluconeogenesis is a marked
increase in glycogen storage in the liver cells.
2) On protein metabolism
A. Cortisol mobilizes amino acids from the
nonhepatic tissues and diminishes the tissue stores of
protein.
B. Cortisol decreases protein synthesis in body cells
except those of the liver and increases catabolism of
protein in many extrahepatic tissues especially in
muscle and lymphoid tissue.
C. In the presence of great excesses of cortisol, the
muscles become weak and the immunity functions of
lymphoid tissue decrease.
3) On fat metabolism
A. Cortisol promote mobilization of fatty acids from adipose
tissue which increases the concentration of free acids in the
plasma
B. Increases oxidation of fatty acids in the liver cells for
energy.
Cushing s
Syndrome
Many people with
excess cortisol
secretion develop a
peculiar type of
obesity, with excess
deposition of fat in
the chest and head
regions of the body,
giving a buffalo-like
torso and a rounded
face, a moon-face.
Cushings
Syndrome
moon
face
striae
CORTISOL
AND
FOODSTUFF
METABOLISM
(3) Feedback
mechanism
Cortisol has direct
negative feedbacks on
the hypothalamus to
decrease formation of
CRH
High circulating
levels of cortisol
inhibit secretion and
formation of ACTH,
decreasing response
of anterior pituitary
gland to CRH.
SECTION 5:
PARATHYROID GLAND,
VITAMIN D
AND PARAFOLLICULAR CELLS
SELF-STUDY