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BCCS,PALMER PITS,JAW
CYSTS
Recurrent,child,pruritis,bullous
eruption,diagnosis?
Genetic,blistering
disorder,diagnosis?
Dermatitis herpatiformis
During disease
Related to coelic
disease
Involves IG A
antibodies
There is intolerence to
gliaden fraction of
gluten
2/3 are males
Association with hla
dq2dq8
Pruritis severe
Vesicles and excoriated
papules
Symmetrical distribution
Scalp,shoulders,buttock,el
bows and knees
Hyper or
hypopigmentation is seen
Small bowel villous atrophy
Dapsone,sulphapyridine
Gluten free diet
What is the
diagnosis?
TREATMENT
Systemic steroid ;
2 to 3 mg/kg of prednisolone until cessation of new blister formation and disappearance of Nikolsky sign.
9 months history
Biopsy shows
tuberculoid
granulomatous
inflamation
Give diagnosis
Name drugs used
Tuberculosis
Tuberculids
Leprosy
Leishmaniasis
Late syphilis
Lupus miliaris
desseminatus facie
Crohns disease
Rosacea
GRANULOMATOUS
CHEILITIS
GRANULOMATOUS CHIELITIS
RECURRENT FACIAL
PARALYSIS
SWELLING OF THE
LIPS
SOME TIMES OF
THE FACE
THIS MAY BE
FAMILIAL
ETIOLOGY IS
UNKNOWN
HISTOPATHOLOGY
SHOWS
TUBERCULOID
GRANULOMATOUS
INFLAMATION
MAFFUCI SYNDROME
MULTIPLE HAEMANGIOMAS
MULTIPLE ENCHONDROMAS
RISK OF DEVELOPING PANCREATIC
TUMOURS,OVARION TUMOURS,CNS
TUMOURS
pruritic
skin
eruption
Name 3
diseases
presentin
g in such
fashion
PSORIASIS
LICHEN PLANUS
LICHEN STRIATUS
LINEAR EPIDERMAL NEVUS
NEVOID LENTIGINOSIS
POROKERATOSIS
MORPHEA
CERTAIN INFECTIONS
ROTHMAN THOMSON
SYNDROME
AUTOSOMAL
RECESSIVE
POIKILODERMA ON
THE
CHEEKS.,HANDS,B
UTTOCKS,
30% CASES SHOW
HYPOGONADISM,
PHOTOSENSITIVITY
SHORT STATURE
SPARSNESS OF
EYEBROWS,EYLASHES
,
ALOPECIA OF SCALP
CONGENITAL BONE
DEFECTS
SQUAMOUS CELL
CARCINOMA,BASAL
CELL CARCINOMA MAY
DEVELOP
BLOOM SYNDROME
Autosomal recessive
disorder characterized
by telangiectases
photosensitivity
, SHORT STAURE
immunodeficiency,
increased susceptibility
to neoplasms .
HIGH PITCHED VOICE.
Prominent nose and ears
hypogonadism]
Psoriasiform infiltrated
plaques
Biopsy shows
granulomatous
inlammation
with many
eosinophils
Clinical variants:
(1) Localized - Children & young adults. Papules &
annular or arciform plaques.
Site: Hands, feet, arms & legs.
(2) Generalized - Middle aged and elderly patients.
Multiple macules, papules or nodules.
Site: Trunk & limbs.
(3) Perforating - Middle aged & elderly females.
Papules & annular plaques. Scaling & crusting with
central umbilication may be present.
Site: Dorsa of the hands and feet.
(4) Subcutaneous or deep form - Children & young
adults. Solitary or multiple nodules (a few
millimeters to several centimeters in size).
Site: Lower extremities, dorsa of the hands & feet,
buttock and scalp.
Acanthosis Nigricans
Seen in situations of insulin resistance
Besides in DM, also seen in the following:
Pathogenesis
WOOD LAMP
EXAMINATION
SHOWS CORAL
RED FLORESCENCE
Gottron papules
What is the diagnosis?
2.
Dermatomyositis
Heliotrope erythema:
edema
erythematous
Gottrons
sign: scaling macules and papules dorsa
Periungual erythema
LIVEDO RETICULARIS
MOTLED DISCOLOURATION DUE TO
CAPPILARY DILATATION AND
STAGNATION OF BLOOD WITHIN IT.
CUTANEOUS DISCOLORATION
SURROUNDING PALE CENTRAL AREAS.
IDEOPATHIC
VASCULITIS.SLE,DERMATOMYOSITIS,AN
TIPHOSPHOLIPID SYNDROME
RHEUMATOID ARTHRITIS,TB.
Child
Fever with skin
peeling
oral mucosa not
involved
PROGNOSIS GOOD
Stevens-Johnson syndrome
Acute, and self-limiting
Hypersensitivity to drugs or infection
Typically affects young men
Give DDS
Tuberous sclerosis
Seizures
Mental retardation
Slow growth
AD
Angiofibromas
Periungual fibroma
Shagreen patgh
Ash leaf spots
Bazexs Syndrome
BAZEX SYNDROME
It is also known as acrokeratosis
neoplastica
Nail dystrophy with painful
paronychia
Scaly eruption on the face
Keratoderma of hands and
feet,honey comb appearance
Squamous ca. of upper res. Tract
upper GIT tract
More common in males
Hand-Foot-Mouth:
Enanthem
Hand-Foot-Mouth:
Exanthem
Hand-Foot-Mouth Disease
Hand-foot-and-mouth disease (HFMD) is a
viral illness with a distinct clinical
presentation of oral and characteristic
distal extremity lesions
Usually Coxsackie A16
At risk: preschool children
Incubation period
Prodrome: 1-2 days before rash
Low grade fever, anorexia, malaise, sore mouth
Generalized pruritus
without an eruption
Causes:
Idiopathic (senile)
Iron deficiency
Liver disease
Neurological disorders
Polycythemia
Renal failure
Thyroid dysfunction
immunoflorescence
Used to find the presence of antibodiies
attached to the antigens in tissues
Flourescene linked antibodies are used
Fluorescin isothiocyanate is used
Direct immunoflorecence
Indirect immunoflorescence
Complement indirect immunoflouresence
Salt split technique
Liquid nitogen,slid carbone dioxide,hexane
bath or Michal solution