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Whats the Question?

Come up with some questions where the key


words below are the answers:
Open circulatory system
Blood vessels
Body cavity
Ostia
Low pressure
Tissue fluid
Lumen
Endothelium
Elastic fibres
Smooth muscle
Collagen fibres
High pressure

Blood, Tissue Fluid and Lymph


By the end of the lesson you will be able to:
Explain the differences between blood, tissue fluid
and lymph. (E)
Describe how tissue fluid is formed from plasma.
(C)
Explain how effective blood pressure determines
the direction of fluid movement. (A)

Key definition
Blood is the liquid held in our arteries,
veins & heart.
Tissue fluid bathes the cells of individual
tissues
Lymph is held within the lymphatic system

Blood composition

Plasma
-55%
RBC
-40%
WBC
-5%

Tissue fluid
Bathes the cells of a tissue (hence the
name!)
Similar to blood (plasma) but without the
cells or plasma proteins.
Its job is to transport oxygen and nutrients
to the cells from the blood and carbon
dioxide and other wastes back to the
blood from the cells.

Artery linked
to a vein by a
capillary bed

How is tissue fluid formed?


Blood flows into a capillary in an organ
The blood is under high pressure at the arteriole
end of the capillary bed
This is hydrostatic pressure
This tends to push the blood fluid out of the
capillaries through tiny gaps in the wall
The fluid consists of plasma with dissolved
oxygen and nutrients
RBC & WBC are too large to be pushed out-as
are plasma proteins
Exchange of gases and nutrients takes place
across plasma membranes by diffusion or
facilitated diffusion

Artery linked
to a vein by a
capillary bed

A single capillary showing the relative hydrostatic and osmotic


(water potential) forces

Arteriole End Worked Example


Effective HP = 4.3 1.1 = 3.2kPa
Effective SP = -3.3 (-1.3)= -2kPa
Effective blood pressure = 3.2 2 = 1.2kPa
Therefore fluid pushed out of capillary

How does fluid return to the blood?


The hydrostatic pressure of the blood is not the
only force acting on the fluid. The fluid itself has
some hydrostatic pressure.
This tends to push the fluid BACK into the
capillaries.
Both the blood and tissue fluid contain solutes
giving them a negative water potential.
The water potential of the tissue fluid is less
negative than that of the blood.
Therefore water moves back into the blood from
the fluid by OSMOSIS.

Now calculate the effective blood pressure and direction of flow


for the venous end: Venous End Values (kPa):
In capillary:
HP = 1.6 SP = -3.3
In tissue fluid:
HP = 1.1 SP = -1.3

A single capillary showing the relative hydrostatic and osmotic


(water potential) forces

Venous End Worked Example


Effective HP = 1.6 1.1 = 0.5kPa
Effective SP = -3.3 (-1.3)= -2kPa
Effective blood pressure = 0.5 2 = -1.5kPa
Therefore fluid pushed into the capillary

Formation of lymph

Not all tissue fluid is returned to the blood


capillaries
Excess fluid drains into the lymphatic system
Eventually the lymph rejoins the blood
It is similar in composition but with less oxygen
and fewer nutrients, and fatty material that has
been absorbed from the intestines
Lymph contains lymphocytes which are produced
at lymph nodes and which filter bacteria from the
fluid
This is part of our immune system which protects
against infection

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