Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
INDOLYL QUINOLINES
N
SRN 23rd Oct 02
Initial SPOS route to Indolyl Quinolines
120
100
80 Ciprofloxacin
Inhibition
60 155342
40 118843
20
0
2 4 6 8 12 22
Time
Protein synthesis
120
100
80 Chloramphenicol
Inhibition
60 155342
40 118843
20
0
2 4 6 8 12 22
Time
120
100
80 Rifampicin
Inhibition
60 155342
40 118843
20
0
2 4 6 8 12 22
Time
Peptidoglycan synthesis
120
100
80 Vancomycin
Inhibition
60 155342
40 118843
20
0
2 4 6 8 12 22
Time
Lipid Synthesis
120
100
80
Inhibition
Cerulenin
60 155342
40 118843
20
0
2 4 6 8 12 22
Time
Conclusions:
This class of molecules may de-energize the
cytoplasmic membrane thus leading to relA
independent cell lysis. (resembles sodium azide)
There is considerable
scope for variation at
posns 3 & 4 of the
tetrahydroquinoline.