Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Physical Characteristics of
Blood
Thicker (more viscous) than water and flows more
slowly than water
Temperature of 100.4 degrees F
pH 7.4 (7.35-7.45)
8 % of total body weight
Blood volume
5 to 6 liters in average male
4 to 5 liters in average female
hormonal negative feedback systems maintain constant
blood volume and osmotic pressure
Functions of Blood
Transportation
O2, CO2, metabolic wastes, nutrients, heat &
hormones
Regulation
helps regulate pH through buffers
helps regulate body temperature
coolant properties of water
vasodilatation of surface vessels dump heat
helps regulate water content of cells by
interactions with dissolved ions and proteins
Blood components
55% plasma: 7 to 8% dissolved substances
(sugars, amino acids, lipids & vitamins), ions,
dissolved gases, hormones
most of the proteins are plasma proteins: provide a
role in balancing osmotic pressure and water flow
between the blood and extracellular fluid/tissues
loss of plasma proteins from blood decreases
osmotic pressure in blood and results in water flow
out of blood into tissues swelling
most common plasma proteins: albumin, globulins,
clotting proteins (fibrin)
-release histaminase
hypersensitivity (allergic)
Blood Plasma
FORMED ELEMENTS OF
BLOOD
Red blood cells ( erythrocytes )
White blood cells ( leukocytes )
granular leukocytes
neutrophils
eosinophils
basophils
agranular leukocytes
lymphocytes = T cells, B cells, and natural
killer cells
monocytes
HAEMOGLOBIN
Iron-containing protein
Binds strongly, but reversibly, to oxygen
Each hemoglobin molecule has four oxygen binding sites
Each erythrocyte has 250 million hemoglobin molecules
Hematocrit
Percentage of blood occupied by cells
female normal range
38 - 46% (average of 42%)
Anemia
not enough RBCs or not enough hemoglobin
Polycythemia
too many RBCs (over 65%)
dehydration, tissue hypoxia, blood doping in athletes
Erythropoiesis: Production of
RBCs
Erythrocyte formation, called erythropoiesis, occurs in
adult red bone marrow of certain bones.
The main stimulus for erythropoiesis is hypoxia.
Proerythroblast starts to produce hemoglobin
Many steps later, nucleus is ejected & a reticulocyte is
formed
orange in color with traces of visible rough ER
Reticulocytes escape from bone marrow into the blood
In 1-2 days, they eject the remaining organelles to
become a mature RBC
ANEMIA
Symptoms
oxygen-carrying capacity of blood is reduced
fatigue, cold intolerance & paleness
lack of O2 for ATP & heat production
Types of anemia
iron-deficiency = lack of absorption or loss of iron
type of nutritional anemia
failure to take in essential raw ingredients not made by the body
pernicious = lack of intrinsic factor for vitamin B12 absorption from
the digestive tract
B12 is essential for normal RBC formation and maturation
binding of B12 to intrinsic factor allows its absorption
intrinsic factor synthesized by the small intestine
Types of Leukocytes
Granulocytes
Granules in their cytoplasm can be stained
Include neutrophils, eosinophils, and basophils
Agranulocytes
Lack visible cytoplasmic granules
Include lymphocytes and monocytes
Granulocytes
Neutrophils
Multilobed nucleus with fine granules
Act as phagocytes at active sites of infection
Fastest response of all WBC to bacteria
Direct actions against bacteria
release lysozymes which destroy/digest bacteria
release defensin proteins that act like antibiotics &
poke holes in bacterial cell walls destroying them
release strong oxidants (bleach-like, strong
chemicals ) that destroy bacteria
Eosinophils
Large brick-red cytoplasmic granules
Found in repsonse to allergies and parasitic
worms
Leave capillaries to enter tissue fluid
Release histaminase
slows down inflammation caused by basophils
Basophils
Have histamine-containing granules
Initiate inflammation
Involved in inflammatory and allergy reactions
Leave capillaries & enter connective tissue as mast
cells
Release heparin, histamine & serotonin
heighten the inflammatory response and account for
hypersensitivity (allergic) reaction
Agranulocytes
Monocytes
Largest of the white blood cells
Function as macrophages
Important in fighting chronic infection
Take longer to get to site of infection, but arrive in larger numbers
Become wandering macrophages, once they leave the capillaries
Destroy microbes and clean up dead tissue following an infection
Lymphocytes
Nucleus fills most of the cell
Play an important role in the immune response
B cells
destroy bacteria and their toxins
turn into plasma cells that produces antibodies
T cells
attack viruses, fungi, transplanted organs, cancer cells
& some bacteria
Natural killer cells
attack many different microbes & some tumor cells
destroy foreign invaders by direct attack
Platelets
Derived from ruptured multinucleate cells (megakaryocytes)
Needed for the clotting process
Normal platelet count = 300,000/mm3
HEMOSTASIS
A clot is a gel consisting of a network of insoluble protein
fibers (fibrin) in which formed elements of blood are trapped.
The chemicals involved in clotting are known as coagulation
(clotting) factors; most are in blood plasma, some are
released by platelets, and one is released from damaged
tissue cells.
Blood clotting involves a cascade of reactions that may be
divided into three stages: formation of prothrombinase
(prothrombin activator), conversion of prothrombin into
thrombin, and conversion of soluble fibrinogen into insoluble
fibrin.
Blood Clotting
Blood drawn from the body thickens into a gel
gel separates into liquid (serum) and a clot of insoluble
fibers (fibrin) in which the cells are trapped
If clotting occurs in an unbroken vessel is called a
thrombosis
Substances required for clotting are Ca+2, enzymes
synthesized by liver cells and substances released by
platelets or damaged tissues
Clotting is a cascade of reactions in which each clotting
factor activates the next in a fixed sequence resulting in the
formation of fibrin threads
prothrombinase & Ca+2 convert prothrombin into
thrombin
thrombin converts fibrinogen into fibrin threads
Extrinsic Pathway
Damaged tissues leak tissue factor
(thromboplastin) into bloodstream
Prothrombinase forms in seconds
In the presence of Ca+2, clotting factor X
combines with V to form prothrombinase
Intrinsic Pathway
Activation occurs
endothelium is damaged &
platelets come in contact with
collagen of blood vessel wall
platelets damaged & release
phospholipids
Requires several minutes for reaction
to occur
Substances involved: Ca+2 and
clotting factors XII, X and V