BASAL CELL CARCINOMA

Yono Hadi Agusni

Dept of
Dermatovenereology
Padjadjaran University

Basal cell carcinoma

Sinonim :
- Basal cell epithelioma
- Basalioma
- Ulcus roden / Rodent ulcer

Basal cell carcinoma

Malignant tumor of the skin that is

believed to arise from the hair
follicle

( David J. Leffell & David A. Fitzgerald)

EPIDEMIOLOGY
US
: 146 per 100.000
Australia : 726 per 100.000
Over the past decade, significant
increases the incidence oc BCC have
been observed in Europe, Australia
and United States
Indonesia : ?

 Age

: over 40 years

Sex

Race :
skinned

male more than female

rare in black / brown

Predisposing factors
Agents
Skin Lesions
Syndromes
Settings

Predisposing agents
Ultraviolet light
Ionizing radiation
Chemical carcinogens

Predisposing skin
lesions
Dermatofibromas
Nevus sebaceous
Burns scars, Chronic ulcers
Linear unilateral basal cell nevus
Stanley J. Miller)

Predisposing syndromes
Xeroderma pigmentosum
Nevoid basal cell carcinoma
syndrome
Bazex syndrome

(Stanley J. Miller)

Predisposing settings
Immunosuppression
Genetic tendency
Stanley J. Miller

Physical examination

Distribution : sun-exposed area

(1)

Physical examination (2)

Skin lesions :

Papule or nodule

translucents or pearly

rodent ulcer

(ulcer with a rolled border)

Physical examination

(3)

Color : Pink or red

Brown to Black
Palpation

: Hard , firm
Cystic lesion may occur

Shape : Round, oval, depressed centre

(umbilicated)

Variants :
Noduloulcerative type
Sclerosing type (morphea-like
type)
Superficial (multicentric) type
Pigmented type

-William A. Caro
- Thomas B. Fitzpatrick

Laboratory findings

None

Pathology anatomy :
Site : Epidermis & dermis
Process : Proliferating atypical
basal cells (large, oval, deep-blue
staining on H&E, but with a little
anaplasia and infrequent mitoses)
with variable amounts of stroma.
Thomas B. Fitzpatrick

Different diagnosis
Squamous cell carcinoma
Keratoacanthoma
Nevus pigmentosus
Chronic ulcer

Complications :
BCC have a little tendency to
metastasize
BCC invade and destroy underlying
tissue
destruction of underlying tissue
makes
BCC lookslike malignant

Treatments
Excision
Cryosurgery
Curettage
Electrosurgery
Radiotherapy

MOHS surgery
Mohs micrographyc surgery is a
technique by which skin cancer are
excised with complete, three
dimensional microscopic control of all
surgical margins, allowing the
detection and excision of all
subclinical tumor extensions.

Nicholas R. Telfler/clinic in dermatol

Prognosis

In general :

good