Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
in Complementary and
Alternative Medicine
Michael J. Wargovich, Ph.D.
University of South Carolina
School of Medicine and
South Carolina Cancer Center
Columbia, SC 29203
Gallup, 1995
Prevention,
1997
Harris, 1998
Counseling/psychotherapy
Diet and exercise
Massage
Acupuncture
Chiropractic
Homeopathic medicine
Herbal medicine
97%
92
57
56
49
27
3
12%
12
42
49
46
62
68
NCCAM
www.nccam.nih.gov
www.nccam.nih.gov
Minneapolis Medical
Research Center
U Michigan
Harvard
*
* Columbia Penn
*U Illinois
**
* Kessler Institute
*
Purdue
For Rehabilitation
*
Johns Hopkins
U MD School of Medicine
*
Stanford
U Iowa *
UC Davis
U Arizona
*
UCLA
U VA School of Nursing
Uncontrolled trials
Observational studies
Case Studies
Anecdotes
Mind-Body Methods
Herbal Therapy
Energy Therapies
Ayurvedic Medicine
Science of Life
Clinical Trial!
Qigong
Ginkgo biloba
Gingko biloba
Clinical Trial!
150 Hep C+
Cirrhotic Patients
5 yrs
Placebo
HCC
Green Tea
Tea Hypotheses
Tea Antioxidants
OH
3'
HO
O
A
OH
4'
OH OH
C
5
OH
H3C
OH
O
OH
CH3
N
N
N
CH3
Caffe ine
(1 ,3,7-trime thylxanthine )
Ecological Studies
Cohort Studies
Case-Control Studies
Male
Female
p (trend) = 0.20
1.00
0.50
0.00
cups/day
none
<1.5
>1.5
cups/day
none
<1.5
>1.5
No
nus
<
1.
er
5
cu
ps
/d
>
ay
1.
5
cu
ps
/d
ay
>1.5
No
nus
<
1.
er
5
cu
ps
>
/d
1.
ay
5
cu
ps
/d
ay
none <1.5
No
nus
<
1.
er
5
cu
ps
/d
>
ay
1.
5
cu
ps
/d
ay
Relative Risk .
1.50
cups/day
Widely used as an
antidepressant in Europe
use of alcohol in alcohol
dependent rats
Acts like SSRI (Prozac)
Side effect: coumadin
metabolism
Side effect: tamoxifen
metabolism
Hypericum perforatum
Clinical Trial!
Clinical Trial!
University of Maryland
Herbal
NSAIDS...
Epidemiology - NSAIDS
Type of study
RR
ASA Use
Author
Cohort
0.5
15x/mo
Thun
Case-Control
0.5
Continual
Baron
Case-Control
0.4
Habitual
Mettlin
Case-Control
0.4
Habitual
Kune
Cohort
0.49
Non-ASA
Smalley
NSAIDS for 4 y
Herbal NSAIDS
Devils Claw
Harapagophytum
procumbens
Willow Bark
Salix alba
Feverfew
Tanacetum parthenium
Bioflavonoids
Quercetin
Quercetin in Foods
Functions as an antioxidant
Endothelial Cells
OXIDATION
Oxidized LDL
20-30 mg/d
>31 mg/d
Number of
subjects
268
268
269
Deaths
22
11
10
Adjusted
RR
1.0
0.32 (0.15-0.68)
0.32 (0.15-0.71)
Agent
Cabbage, kale,
etc.
Garlic, Onion
Isothiocyanates
Citrus Fruits
Monoterpenes
Tomatoes
Tea
Lycopene
carotenoids
Cathechins
Tumeric
Curcumin
Organosulfur
cpds
Protects
Against
Lung cancer
Colon cancer
Esophageal
cancer
Pancreas
cancer
Lung cancer
Skin cancer
Breast, skin
cancer