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- flubendiamide -
The Next Generation in Lepidoptera
Pest Management in Cotton

Alan Hopkins, Shane Hand,
Jon Mixson and Steve Krueger












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1
st
compound of new chemical class (phthalic acid diamides)
Newly discovered mode of action = interrupts the Ca
2+
balance as an
ingested stomach poison
Considered harmless to pollinators and beneficials
Environmentally-friendly with favorable tox, ecotox, e-fate profile
IPM / IRM friendly
REI
*
= 12 hours (all crops)
PHI
*
= 1 day (all veggies)
Apps by air / ground / chemigation
*

Highly rainfast (once dry)
Low rates = low env. loading
Excellent crop safety
* Proposed labels
I
N
H
O
SO
2
CH
3
C H
3
CH
3
N H
O
C H
3
CF
CF
3
CF
3
Chemical Properties = The Nuts n Bolts












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Target Pests: Lepidoptera (broad-spectrum)
evaluating activity on secondary pests
Other
Target Crops: The active ingredient will also be registered for use in
vegetables, grapes, fruits, tree nuts, citrus, and corn

Mode of action: => unmatched larvicidal activity
=> orally-ingested intoxicant
=> fast acting: rapid cessation of feeding (hrs)
=> long lasting: rainfast and residual (weeks)
=> novel biochemical target
=> Ca
2+
balance, stomach poison
=> no known cross-resistance

Formulation: BELT 4SC in cotton
Biological Characteristics












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Insects Controlled
Highly active against larval stages of
a broad range of lepidopteran pests.

Includes a host of difficult to control
pests, including armyworm complex,
looper complex, bollworm and
budworm.












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Data Completion: November, 2005
EPA Submission: April, 2006
Anticipated Reg: 2007
Full US Launch: 2008

Registration Timeline












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68
77
84
85
86
73
77
89
63
89
84
79
77
60
96
70
84
95
65
89
0
20
40
60
80
100
120
1 2 3 4
%

C
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Arlene Kurakowa,
Bayer CropScience
Fresno, California
% Control of Fall Armyworm
70g (2oz) 105g (3oz)
1 = Belt 4SC 70g (2oz)
2 = Belt 4SC 88g (2.5oz)
3 = Belt 4SC 105g (3oz)
4 = Tracer 2oz
88g (2.5oz)
7 DAA
14 DAA, 4 DAB
21 DAA, 11 DAB
24 DAA, 14 DAB, 3 DAC
30 DAA, 20 DAB, 9 DAC
Tracer (2oz)












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80
78
79
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0
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120
1 2 3 4
%

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% Control of Fall Armyworm
70g (2oz) 105g (3oz)
1 = Belt 4SC 70g (2oz)
2 = Belt 4SC 88g (2.5oz)
3 = Belt 4SC 105g (3oz)
4 = Tracer 2oz
88g (2.5oz)
Seasonal Mean for Evaluations
7DAA and Beyond
Tracer (2oz)
Arlene Kurakowa,
Bayer CropScience
Fresno, California












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95
96
98
94
0
20
40
60
80
100
120
1 2 3 4
%

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% Control of Bollworm and Tobacco Budworm
(Evaluation of Damaged Squares)
70g (2oz) 105g (3oz)
1 = Belt 4SC 70g (2oz)
2 = Belt 4SC 88g (2.5oz)
3 = Belt 4SC 105g (3oz)
4 = Tracer 2oz
88g (2.5oz) Tracer (2oz)
Evaluation 9 days
after third application
John Curtis,
Bayer CropScience
Molino, FL












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Total Number of Larvae
0
10
20
30
7
/
1
3
/
2
0
0
7
7
/
1
5
/
2
0
0
7
7
/
1
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/
2
0
0
7
7
/
1
9
/
2
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0
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7
/
2
1
/
2
0
0
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3
/
2
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0
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7
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2
5
/
2
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0
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7
/
2
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/
2
0
0
7
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/
2
9
/
2
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0
7
7
/
3
1
/
2
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0
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8
/
2
/
2
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0
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4
/
2
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6
/
2
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N
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L
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Untreated Check BELT (2 oz) BELT (2.5 oz)
BELT (3 oz) TRACER (2.5 oz)
Influence on Seasonal Heliothine Larvae
(Dr. Gus Lorenz, University of Arkansas)
Applications on July 10 and 20. Data collected from 6 evaluations.












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Total Number of Larvae
0
10
20
30
7
/
1
3
/
2
0
0
7
7
/
1
5
/
2
0
0
7
7
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1
7
/
2
0
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7
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1
9
/
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7
7
/
2
1
/
2
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0
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2
3
/
2
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7
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2
5
/
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0
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2
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/
2
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2
9
/
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3
1
/
2
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2
/
2
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4
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2
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6
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Untreated Check BELT (2 oz) BELT (2.5 oz)
BELT (3 oz) TRACER (2.5 oz) DENIM (8 oz)
STEWARD (1.6 oz)
Influence on Seasonal Heliothine Larvae
(Dr. Gus Lorenz, University of Arkansas)
Applications on July 10 and 20. Data collected from 6 evaluations.












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Total Number of Larvae
0
20
40
60
80
100
7
/
1
3
/
2
0
0
7
7
/
1
5
/
2
0
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1
7
/
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1
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1
/
2
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2
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/
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/
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3
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/
2
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2
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4
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2
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2
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F
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Untreated Check BELT (2 oz) BELT (2.5 oz)
BELT (3 oz) TRACER (2.5 oz)
Influence on Seasonal Heliothine Damage
(Dr. Gus Lorenz, University of Arkansas)
Applications on July 10 and 20. Data collected from 6 evaluations.












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Total Number of Larvae
0
20
40
60
80
100
7
/
1
3
/
2
0
0
7
7
/
1
5
/
2
0
0
7
7
/
1
7
/
2
0
0
7
7
/
1
9
/
2
0
0
7
7
/
2
1
/
2
0
0
7
7
/
2
3
/
2
0
0
7
7
/
2
5
/
2
0
0
7
7
/
2
7
/
2
0
0
7
7
/
2
9
/
2
0
0
7
7
/
3
1
/
2
0
0
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8
/
2
/
2
0
0
7
8
/
4
/
2
0
0
7
8
/
6
/
2
0
0
7
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/
8
/
2
0
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7
N
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o
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D
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e
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F
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Untreated Check BELT (2 oz) BELT (2.5 oz)
BELT (3 oz) TRACER (2.5 oz) DENIM (8 oz)
STEWARD (1.6 oz)
Influence on Seasonal Heliothine Damage
(Dr. Gus Lorenz, University of Arkansas)
Applications on July 10 and 20. Data collected from 6 evaluations.












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Flubendiamide is the first compound of the new
chemical class: phthalic acid diamides.
Newly discovered mode of action: interrupts the
Ca
2+
balance as an ingested stomach poison.
Bayer CropScience expects registration of the
active ingredient in several crops including cotton.
Provides excellent control of several lepidopteran
pests of cotton, including the Heliothine complex.
Registration is expected in time for launch in 2008.
Summary












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