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Twinpregnancy represents 2 to 3% of all pregnancies. Risk factors 1assisted reproductive techniques (IVF& induction of ovulation) 2-high parity 3-black race 4maternal family history 5increasing maternal age.
Twinpregnancy represents 2 to 3% of all pregnancies. Risk factors 1assisted reproductive techniques (IVF& induction of ovulation) 2-high parity 3-black race 4maternal family history 5increasing maternal age.
Twinpregnancy represents 2 to 3% of all pregnancies. Risk factors 1assisted reproductive techniques (IVF& induction of ovulation) 2-high parity 3-black race 4maternal family history 5increasing maternal age.
Two or more fetus simultaneously develops in the uterus is called multiple pregnancy. Prevalence Twinpregnancy represents 2 to 3% of all pregnancies.
Risk factors 1- assisted reproductive techniques (IVF& induction of ovulation ) 2-high parity 3- black race 4- maternal family history 5- increasing maternal age.
VARIETIES Dizygotic twins fom two ova Non identical twins *Always have two separate placentas (DC) *separate amniotic cavities (DA) *the fetuses either the same or different sex pairing Monozygotic twins from single ova Identical twins Arise from fertilization of single egg Always of same sex Either MC or DC
Types of monozygotic twins Results from division of fertilized egg: 0-72 H. Diamniotic dichorionic. 4-8 days Diamniotic monochor. 9-12 days Monoamnio.monochor. >12 days Conjoined twins.
70% are diamniotic monochorionic.
30% are diamniotic dichorionic Conjoined twins or Siamese twins *Anterior (thoracopagus) *Posterior (pygopagus) *Cephalic (craniopagus) *Caudal (ischiopagus) Results from division of fertilized egg: 0-72 H. Diamniotic dichorionic. 4-8 days Diamniotic monochor. 9-12 days Monoamnio.monochor. >12 days Conjoined twins.
Maternal Physiological Adaptation Increase blood volume and cardiac output. Increase demand for iron and folic acid. Maternal respiratory difficulty. Excess fluid retention and edema. Increase attacks of supine hypotension. Complications of pregnancy 1- preterm labour 2-pregnancy-induced hypertension 3-anaemia 4-polyhydramnia 5-congenital malformation 6- growth restriction 7-miscarriage 8- high perinatal mortality & morbidity Complication of labour 1-malpresentation 2-postpartum haemorrhage 3-cord prolapse 4- locked twins In monochorionic twins death of one fetus may result in immediate complications in the survivor (brain damage ,death, neurodevelopment handicap) Acute hypotensive episodes secondary to placental vascular anastamosis between the two fetuses result in haemodynamic volume shifts from the life to the dead fetus. Fetal abnormalities The risk of fetal abnormalities carry at least twice the risk in twins pregnancy *In each DC twins the risk of structural abnormalities ,such as spina bifida is similar to that for singleton pregnancy *Each MC twins carries the risk 4 X that of singleton pregnancy Multiple gestations with an abnormality in one fetus can be managed expectantly or by selective fetocide of the affected fetus 1-When the abnormality is not lethal the parents should outweighs the risk of loss of a normal fetus from fetocide related complications
When the abnormality is lethal it may better to avoid such risk to the fetus In MC twins selective fetocide is dangerous for the second twins so they do cord occlusion techniques, these require significant instrumentation of the uterus & are therefore associated with higher complications. Chromosomal defects & twining 1-monozygotic twins are affected either both or non of the twins will be affected ( the risk is based upon maternal age) 2- in DZ twins the risk will be twice that of singleton pregnancy ( e.g. the risk of Down syndrome 1/50) Differential diagnosis of twin pregnancy 1-polyhydramnious 2-big baby 3-ovarian cyst or mass 4-uterine fibroid 5-retention of urine. TWIN-TWIN transfusion Chronic shunt occurs ,the donor bleeds into the recipient so one is pale with oligohydraminos while the other is polycythemic with hydraminos.
If not treated death occurs in 80-100% of cases. Complications unique to monochorionic twins Twin twin transfusion syndrome Either mild , moderate or sever depends on the degree of imbalance the donor fetus suffers from 1- hypovolaemia & hypoxia 2-growth restricted 3- oliguric 4-oligohydramnious The recipient fetus suffers 1-hyprrvolaemic 2-polyhydraminous 3- myocardial damage 4- high output failure Sever disease appear at18-24w Mother complain of 1- sudden increase in abdominal girth. 2- extreme discomfort 3- polyhydramnious (detcted by US) 90% of TTTS end in miscarriage or preterm labour due to polyhydramnious or death of one fetus. Treatment *Amniocentesis every 1-2w *fetoscopically guided laser coagulation to disrupt the placental blood vessels that connect the circulation of the two fetuses Other Complications in Monochorionic Twins: Congenital malformation. Twice that of singleton.
Umbilical cord anomalies. In 3 4 %.
Conjoined twins. Rare 1:70000 deliveries. The majority are thoracopagus.
PNMR of monochorionic is 5 times that of dichorionic twins(120 VS 24/ 1000 births) Diagnosis of Multiple Fetuses 1. History.
2. Clinical Examination.
3. Investigations. History ovulation inducing drug Family history of twin Exaggerated symptoms Cardiopulmonary embarrassment Excessive fetal movement
Per abdominal examination Height of the uterus more than the period of gestation Too many fetal parts Two fetal head Two distinct fetal heart sound, at separated spot, provided the difference at least 10 beats per minute Lab Investigation Ultrasonography Two gestational sacs can be detected as early as 10 weeks of pregnancy Radiography Should be done after 30 weeks General examination Anaemia more than single pregnancy Unusual weight gain Management 1. Antenatal. 2. In Labor. Antenatal Management Early diagnosis (mainly by ultra sound)
Adequate nutrition:- 1- Caloric consumption increased by 300 Kcal per day. 2- Iron 60-100 mg per day. 3- Folic acid 1mg per day.
Frequent prenatal visit:- observe maternal and fetal complications 1- Frequent ultra sound fetal growth, congenital anomalies, amniotic fluid. 2- Doppler. 3- BPP(Biophysical profile). Management of twin pregnancy The patient is seen more often than usual from mid- pregnancy onwards . She should be seen every two weeks until 20 weeks & every weeks till 36 weeks Investigations 1-confirming a diagnosis 2-determining chorionicity 3-detecting fetal anomalies 4-evaluating fetal growth 5-confirming fetal wellbeing 6-assisting in delivery Antepartum management 1-Preterm labour (40%) in twin pregnancies &(75%) in triplet pregnancies
*bed rest at home or in the hospital has not proved effective in preventing preterm labour or delivery 2- pre-eclampsia the risk of gestational hypertension or pre-eclampsia has been reported to range from 10-20% in a twin pregnancy, 25-60% in triplet pregnancy. 3- other maternal complications Daily supplementation of at least 60 mg of elemental iron &1mg of folic acid is recommended because of the increased risk of iron &folate deficiency anaemia multiple pregnancy is a particular risk for the occurrence of acute fatty liver of pregnancy Intrapartum management 1- all twin and multiple fetuses should be delivered by 40 weeks 2-the use of prostaglandins for induction & oxytocin for induction or augmentation of labour is an acceptable alternative to the elective delivery by CS 2- requires adequate obstetric & nursing staff 3-US to confirm fetal presentation & size before a decision is made on mode of delivery Four principal combinations of presentations Cephalic/cephalic 60% Cephalic/breech 20% Breech/cephalic 10% Breech/breech 10%
The presentation of the fetuses may be 1- vertex- vertex twins 2- vertex nonvertex twins 3-higher order multiple gestation Vertex- vertex twins In the absence of obstetrical indications for CS delivery ,vaginal delivery should be planned regardless of gestational age. Delay of over half an hour in the delivery of the second twin increases the ocurrence of fetal morbidity, thus the CS rate for the second twin increases with the increase in the delivery time
Vertex nonvertex presentaton Vertex breech or vertex-transerse presentation occurs in 35-40% of all twin pregnancies selection of delivery depends on the following *the size of the second twin *presence of growth discordance The availability of an obstetrician skilled in assisted breech delivery , internal podalic version & total breech extraction If the second twin in a transverse lie or a footling presentation, the membrane should be left intact until the feet can be secured in the pelvis, following which immediate rupture of the membranes & total breech extraction should be performed Nonvertex first twins Breech-vertex or breech-breech occurs in 15-20% of all twin pregnancies. These cases are almost always managed by CS Higher order multiple gestation Cesarean delivery is recomended C.S. for Multiple Pregnancy: Indications of C.S. : More than 2 viable fetuses, if: weight < 2 kg, discordant growth ( i.e.; IUGR or twin-twin transfusion, or disproportionate twins, twin B larger than A (BPD > 2 mm), twin A: is non-vertex. Conjoined Twins Single amniotic cavity (as diagnosed by U/S or amniogram). Previous Uterine scar. During Labor: if delayed progress, fetal distress, or if twin B transverse and cervix is thickened (retained second twin). Associated pregnancy complication i.e.; severe PIH, placenta previa. Contracted Pelvis Lack of expertise Requirements for twin delivery Large delivery room Operating theatre and staff ready Anaesthetist present Senior obstetrician present At least two midwives present Twin resuscitaires Ventous/forceps to hand Blood grouped and saved Intravenous access Neonatologists present Pre-mixed oxytocin infusion ready
Conjoined twins Chang and Eng Bunker (1811-1874), Chinese brothers born in Siam, now Thailand .They traveled with Barnum's circus and were billed as the Siamese Twins .They had fused livers