Morpology Diagnosis

Life cycle Epidemiology

symptom Prevention
Morphology
 Morphology
Life of this worm consist of 2 stages

Large trophozoite
• Trophozoite
Small trophozoite
• Cyst
 bhushan
• Diffn. Between Small trophozoite &
Large trophozoite
• S.trophozoite L.trophozoite
- s. ectoplasm -L.ectoplasm
- RBC (-ve) -- (+ve)
- Non infective - infective.
- Found in luman - it is found in tissue of
of s.intestine. Liver,lung,skin,& brain.
 Function of chromatiod bar &
glycogen vacuole. ( bhushan)

• Chromatiod bar r so called because they

stain with haematoxylin like chromatin.
They contain RNA, DNA, & phosphates.
As the cyst mature the glycogen vacuole &
chromatiod bar r disappears. Both r stores
allergic scores .
Life cycle
Life cycle of E. histolytica

Cyst S. trophozoite Cyst

Lower resistance
Malnutrition Return to lumen of colon
Injury in intestine
L. trophozoite
Brain
Liver
Lung
Ulcer in colon Skin
 Difficulties

• Basic life cycle:

Cyst Small trophozoite Cyst
• This protozoa live in of human
body.
• Infective stage:
• Pathogenic stage:
• Modes of infection:
Pathogenesis and Symptom

• Intestinal Amoebiasis
• Extra-Intestinal Amoebiasis
 Intestinal Amoebiasis
Pathogenesis: In colon, ulcer, bleeding,
inflammation, and perforation
Manifestation
• Acute stage: diarrhea, dysentery, feces
with pus and blood, like chocolate in
color, abdominal pain, flatulence,
anorexia, weight loss,etc.
• Chronic stage: diarrhea, dysentery, feces
thicker than in acute stage, anorexia,
weight loss,etc.
 Extra- Intestinal moebiasis
1. Hepatic abscess
hepatic pain, high fever, enlarged liver,
emaciation, jaundice, etc. The pus looks
like chocolate in color.
2. Pulmonary abscess:
cough, fever, chest pain, sputum with
blood and pus, like chocolate in color,etc.
3. Cerebral abscess
headache, vomiting, nausea, fever, like
bacterial abscess of brain in
manifestations, usually coexisting with
hepatic amoebiasis.
4. Cutaneous ulcer
ulcer of cutaneous tissue, usually found in
the skin near the anus.
Diagnosis
 Epidemiology

1. Distribution
• All over the world, especially in tropic
and sub-tropic area.
• In China, infection incidence of
population nears to 1%
 2. Factors for endemic
• Sources of infection: carriers and the
patients without diarrhea symptom
• A large amount of cysts passed in feces of
infected people every day
• Strong resistance against environmental
factors
• Water and food contamination with cysts
• Fly and other insects transmit the cysts
• Poor conditions of sanitation and ill
personal habits
 Treatment and prevention
1. Treat the patients and carriers
• Metronidazole
• Paromomycin and Indoquinofonum
2. Manage the feces
3. Prevent the feces pollute the water sources
and food
4. Health examination for the food handlers
5. Form good hygienic habits
 Entamoeba coli

The most common amoeba found in

human body, but not a pathogenic one.
What is medical importance of this
protozoa is its confusion with E. histolytica.
 Back
Large trophozoite

Pseudopodium
RBC

Nucleus
 back
Nucleus
nucleus membrane
chromatin
nucleolus
 Compare of L. T. with S. T.
Nucleus
endoplasm
ectoplasm

L.T.
RBC S. T.
 S. trophozoite

L. trophozoite
Back
 back

Cysts of E. histolytica

1 3 1
3 2 2
4
immature immature mature

1: nucleus 2: chromatoid bar

3: glycogen vacuole 4: cyst wall
Immature cyst Back
Mature cyst

Back
Ulcer in cecum
Back
Hepatic abscess

Back
Pulmonary abscess

back
Cutaneous
ulcer

Back
 L. T. Cyst Nucleus

E.h

E.c

Back