Tablet Coating

Why coat tablets?

Types of coatings
sugar coating
film coating
press coating (compression coating)
B. Amsden 1 CH !!"
Sugar Coating
stages in#ol#ed$
sealing of tablet core
subcoating
smoothing
colouring
polishing
printing
B. Amsden % CH !!"
Film Coating
&n#ol#es spraying a solution of polymer ' pigments '
plastici(ers onto a rotated) mi*ed tablet bed to form a
thin) uniform film on tablet surface.
materials
polymers
sol#ents
plastici(ers
colorants
B. Amsden + CH !!"
Coating Process
coating pans
B. Amsden ! CH !!"
The Coating Process
B. Amsden CH !!" ,
Film Formation
late* particles dispersed
in a-ueous phase
formation of thin film .ith
.ater e#aporation through film
continuous film
B. Amsden / CH !!"
Air Flow
B. Amsden CH !!" 0
Coating Process
fluid beds
B. Amsden 1 CH !!"
Important Processing Parameters
inlet and bed temperatures
relati#e humidity
atomi(ation air pressure
li-uid spray rate
droplet si(e
drying time
B. Amsden 2 CH !!"
Coating Problems
pic3ing4chipping
roughness
stic3ing
film crac3ing4peeling
B. Amsden 1" CH !!"
Normal Coating
5escription
6econstitution
le#el
A#erage
.eight
gain
Application e*amples
H78C based
A-ueous
system
119 to 1,9 %., 9
H78C based
:rganic
sol#ent
system
,9 %.,9
H78C based
A-ueous4
:rganic
;ol#ent4
Hydro
Alcoholic
system
A-ueous 119
:rganic ;ol#ent
,9
Hydro Alcoholic
29
%.,9
7<A based
A-ueous
system
%"9 to %,9 %.,9
Amo*ycillin) A(ithromycin) Atenolol)
Amlodipine) Amitriptyline) Ampicilin
Ciproflo*acin) Cephadro*il )
Cimitidine) Calcium Tablets) Citri(ine
) Chloro-uine 7hosphate)
Clarithromycin) rythromycin)
=errous =umarate) =amotidine)
=errous ;ulphate) &buprofen)
&ndapamine) >osartan 7otassium)
>e#amisole) 8ethyl?5opa)
8etronida(ole'Tinida(ole)
8etronida(ole) 8ethyl Coblamine)
8efenamic Acid) 8etoprolol Tartrate)
@orflo*acin) @ifidipine)
@orflo*acin'Tinida(ole) :flo*acin)
7aracetamol) Auinine ;ulphate)
6o*ythromycin) ;ecnida(ole)
;ildenafil Citrate) Trimeta(idine)
Tinida(ole) Tinida(ole?5o*ycycline)
Tinida(ole ' Tetracycline) <erapamil
B. Amsden 11 CH !!"
Enteric-coated
Coating resists dissolution or disruption in stomach but not in
intestines. Bsed for drugs that are unstable) irritating to stomach
B. Amsden 1% CH !!"
5escription
6econstitution
le#el
A#erage
.eight
gain
Application CC e*amples
:rganic nteric
Coating system)
Cellulose Acetate
7hthalate based
, 9 1 9
A-ueous coating
system D :rganic
enteric coating
system. Hydro*y
7ropyl 8ethyl
Cellulose 7hthalate
based system.
:rganic$ ,9
A-ueous$ 1"9
1 9
8ethacrylic acid
copolymer type ECE
B;74@= based
system
A-ueous %"9
Hydro Alcoholic
1"9
:rganic ;ystem
1"9
29
Aspirin) Bisacodyl
5iclofenac ;odium
5o*ylamine ;uccinate
Farlic Tablets) :mepra(ol)
7entapra(ole)
7ento*yfyline) 6abepra(ol )
;errosipeptadise
Press Coating
Bse of compression to form coat around a pre?formed core.
Bsed mainly to separate chemically incompatible materials
also dual release patterns possible
B. Amsden 1+ CH !!"